Genomic features of mecA-positive methicillin-resistant Mammaliicoccus sciuri causing fatal infections in pets admitted to a veterinary intensive care unit

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Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstituto Adolfo Lutz-
Autor(es): dc.contributorMetropolitan University of Santos-
Autor(es): dc.creatorSacramento, Andrey G.-
Autor(es): dc.creatorFuga, Bruna-
Autor(es): dc.creatorMonte, Daniel F.M.-
Autor(es): dc.creatorCardoso, Brenda-
Autor(es): dc.creatorEsposito, Fernanda-
Autor(es): dc.creatorDolabella, Silvio S.-
Autor(es): dc.creatorBarbosa, Ana A.T.-
Autor(es): dc.creatorZanella, Rosemeire C.-
Autor(es): dc.creatorCortopassi, Silvia R.G.-
Autor(es): dc.creatorda Silva, Luciano C.B.A.-
Autor(es): dc.creatorLincopan, Nilton-
Autor(es): dc.creatorSellera, Fábio P.-
Data de aceite: dc.date.accessioned2025-08-21T17:48:54Z-
Data de disponibilização: dc.date.available2025-08-21T17:48:54Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.micpath.2022.105733-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241604-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241604-
Descrição: dc.descriptionMethicillin-resistant staphylococci have become leading cause of infectious diseases in humans and animals, being categorized as high priority pathogens by the World Health Organization. Although methicillin-resistant Staphylococcus sciuri (recently moved to Mammaliicoccus sciuri) has been widely reported in companion animals, there is scarce information regarding their clinical impact and genomic features. Herein, we reported the occurrence and genomic characteristics of methicillin-resistant M. sciuri recovered from fatal infections in pets admitted to an intensive care unit of a veterinary hospital, in Brazil. Two M. sciuri strains were isolated from bronchoalveolar lavage samples collected from dog (strain SS01) and cat (strain SS02) presenting with sepsis and acute respiratory distress syndrome. Both isolates displayed a multidrug-resistant profile, whereas whole-genome sequencing analysis confirmed the presence of the mecA gene, along to genetic determinant conferring resistance to macrolides, streptogramins, aminoglycosides, and trimethoprim. For both strains, the mec and crr gene complex shared high identity (≥97%) with analogue sequences from a M. sciuri isolated from a human wound infection, in the Czech Republic. Strains were assigned to the sequence type ST52 and the novel ST74. Phylogenomic analysis revealed a broad host range association of these strains with several hosts and sources, including humans, animals, food, and the environment through different years and geographic locations. Our findings demonstrate that infections caused by mecA-positive M. sciuri strains can be a serious threat for veterinary intensive care patients and the medical staff, with additional implications for One Health approaches.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Morphology Federal University of Sergipe-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmacy University of São Paulo-
Descrição: dc.descriptionDepartment of Food and Experimental Nutrition Faculty of Pharmaceutical Sciences Food Research Center University of São Paulo-
Descrição: dc.descriptionLaboratory of Avian Pathology Department of Pathology Theriogenology and One Health Sao Paulo State University (FCAV-Unesp), Jaboticabal-
Descrição: dc.descriptionBacteriology Branch Instituto Adolfo Lutz-
Descrição: dc.descriptionDepartment of Surgery School of Veterinary Medicine and Animal Science University of São Paulo-
Descrição: dc.descriptionSchool of Veterinary Medicine Metropolitan University of Santos-
Descrição: dc.descriptionDepartment of Internal Medicine School of Veterinary Medicine and Animal Science University of São Paulo-
Descrição: dc.descriptionLaboratory of Avian Pathology Department of Pathology Theriogenology and One Health Sao Paulo State University (FCAV-Unesp), Jaboticabal-
Descrição: dc.descriptionFAPESP: 2019/15578-4-
Descrição: dc.descriptionFAPESP: 2019/15778-4-
Descrição: dc.descriptionFAPESP: 2020/08224-9-
Descrição: dc.descriptionCNPq: 312249/2017-9-
Descrição: dc.descriptionCNPq: 314336/2021-4-
Descrição: dc.descriptionCNPq: 422984/2021-3-
Descrição: dc.descriptionCAPES: 88882.333054/2019-01-
Descrição: dc.descriptionCAPES: 88887.358057/2019-00-
Descrição: dc.descriptionCNPq: AMR443819/2018-1-
Idioma: dc.languageen-
Relação: dc.relationMicrobial Pathogenesis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCoagulase-negative staphylococci-
Palavras-chave: dc.subjectCompanion animals-
Palavras-chave: dc.subjectMethicillin resistance-
Palavras-chave: dc.subjectStaphylococcus sciuri-
Palavras-chave: dc.subjectVeterinary critical care-
Título: dc.titleGenomic features of mecA-positive methicillin-resistant Mammaliicoccus sciuri causing fatal infections in pets admitted to a veterinary intensive care unit-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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