Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGeneral Hospital of Northern Theater Command (Formerly General Hospital of Shenyang Military Area)-
Autor(es): dc.creatorMarcondes, Mariana Barros-
Autor(es): dc.creatorSusuki, Cíntia Mitsue Pereira-
Autor(es): dc.creatorHokama, Newton Key-
Autor(es): dc.creatorHokama, Paula de Oliveira Montandon-
Autor(es): dc.creatorOliver, Felipe Aguera-
Autor(es): dc.creatorChaib, Paulo Sergio-
Autor(es): dc.creatorQi, Xingshun-
Autor(es): dc.creatorRomeiro, Fernando Gomes-
Data de aceite: dc.date.accessioned2025-08-21T16:04:25Z-
Data de disponibilização: dc.date.available2025-08-21T16:04:25Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12876-022-02477-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241601-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241601-
Descrição: dc.descriptionBackground: Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation: The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions: SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Montenegro, S/N - Distrito de Rubião Junior, São Paulo-
Descrição: dc.descriptionRadiology Department Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionSurgery and Orthopedics Department Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Gastroenterology General Hospital of Northern Theater Command (Formerly General Hospital of Shenyang Military Area)-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Montenegro, S/N - Distrito de Rubião Junior, São Paulo-
Descrição: dc.descriptionRadiology Department Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionSurgery and Orthopedics Department Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2017/25592-9-
Idioma: dc.languageen-
Relação: dc.relationBMC Gastroenterology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAgammaglobulinemia-
Palavras-chave: dc.subjectCase report-
Palavras-chave: dc.subjectCommon variable immunodeficiency-
Palavras-chave: dc.subjectDiarrhea-
Palavras-chave: dc.subjectImmunodeficiency-
Palavras-chave: dc.subjectSerum protein electrophoresis-
Título: dc.titleAre we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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