MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPSL University-
Autor(es): dc.contributorAdam Mickiewicz University-
Autor(es): dc.contributorCNRS-
Autor(es): dc.creatorAbuçafy, Marina Paiva-
Autor(es): dc.creatorFrem, Regina Celia Galvao-
Autor(es): dc.creatorPolinario, Giulia-
Autor(es): dc.creatorPavan, Fernando Rogerio-
Autor(es): dc.creatorZhao, Heng-
Autor(es): dc.creatorMielcarek, Angelika-
Autor(es): dc.creatorBoissiere, Cedric-
Autor(es): dc.creatorSerre, Christian-
Autor(es): dc.creatorChiavacci, Leila Aparecida-
Data de aceite: dc.date.accessioned2025-08-21T16:38:38Z-
Data de disponibilização: dc.date.available2025-08-21T16:38:38Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms23147670-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241597-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241597-
Descrição: dc.descriptionNanoparticles of metal–organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables the concomitant one-pot encapsulation of high loading of an antitumor drug, methotrexate, within the pores of the MOF NPs, and the collagenase enzyme (COL), inside the inter-particular mesoporous cavities, upon the formation of the capsule, enhancing tumor treatment. This association provides better control of the release of the active moieties, MTX and collagenase, in simulated body fluid conditions in comparison with the bare MOF NPs. In addition, the loaded MIL-100 capsules present, against the A-375 cancer cell line, selective toxicity nine times higher than for the normal HaCaT cells, suggesting that MTX@COL@MIL-100 capsules may have potential application in the selective treatment of cancer cells. We highlight that an appropriate level of collagenase activity remained after encapsulation using the spray dryer equipment. Therefore, this work describes a novel application of MOF-based capsules as a dual drug delivery system for cancer treatment.-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry Inorganic Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Science São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitut des Materiériaux Poreux de Paris ESPCI Paris École Normale Supérieure CNRS PSL University-
Descrição: dc.descriptionNanoBioMedical Centre Adam Mickiewicz University-
Descrição: dc.descriptionLaboratoire de Chimie de la Matière Condensée de Paris (LCMCP) Collège de France PSL UMR 7574 Sorbonne Université CNRS, 4 Place Jussieu-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry Inorganic Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Science São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdual release systems-
Palavras-chave: dc.subjectenzyme encapsulation-
Palavras-chave: dc.subjectMOF capsules-
Título: dc.titleMIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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