ARG2 single-nucleotide polymorphism rs3742879 affects plasma arginase 2 levels, nitric oxide formation and antihypertensive therapy response in preeclampsia

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Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorLuizon, Marcelo R.-
Autor(es): dc.creatorPinto-Souza, Caroline C.-
Autor(es): dc.creatorCoeli-Lacchini, Fernanda-
Autor(es): dc.creatorLacchini, Riccardo-
Autor(es): dc.creatorCavalli, Ricardo C.-
Autor(es): dc.creatorSandrim, Valeria C.-
Data de aceite: dc.date.accessioned2025-08-21T15:33:52Z-
Data de disponibilização: dc.date.available2025-08-21T15:33:52Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/pgs-2022-0079-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241589-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241589-
Descrição: dc.descriptionAim: This work examined whether ARG1 (rs2781659, rs2781667, rs2246012 and rs17599586) and ARG2 (rs3742879 and rs10483801) single-nucleotide polymorphisms (SNPs) are associated with antihypertensive therapy responsiveness in preeclampsia (PE) and their effects on arginase isoforms and nitrite concentrations in responsive and nonresponsive patients. Methods: SNP genotypes were determined by TaqMan assays. Plasma arginase levels were measured by ELISA and nitrite concentrations were measured using an ozone-based chemiluminescence assay. Results: The G allele for ARG2 rs3742879 (A>G) was less frequent in nonresponsive compared with responsive patients (15.5% vs 24.7%, respectively) and the G carriers of the nonresponsive subgroup had lower arginase 2 (9.2 ± 7.5 ng/ml vs 19.1 ± 17.3 ng/ml) and higher nitrite concentrations (110.2 ± 52.8 nM vs 78.5 ± 37.9 nM) than carriers of the AA genotype (all p < 0.05). Conclusion: ARG2 SNP rs3742879 is associated with diminished arginase 2 levels and increased nitric oxide formation in nonresponsive PE patients.-
Descrição: dc.descriptionDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais (UFMG), MG-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito Rubiao Junior, Botucatu-
Descrição: dc.descriptionDepartment of Clinical Analyses Toxicology and Food Science School of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo (USP), Ribeirao Preto-
Descrição: dc.descriptionDepartment of Psychiatric Nursing and Human Sciences Ribeirao Preto School of Nursing University of Sao Paulo (USP), Ribeirao Preto-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics University of Sao Paulo (USP), Ribeirao Preto-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito Rubiao Junior, Botucatu-
Formato: dc.format713-722-
Idioma: dc.languageen-
Relação: dc.relationPharmacogenomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectARG2-
Palavras-chave: dc.subjectarginase 2-
Palavras-chave: dc.subjectgenetic polymorphisms-
Palavras-chave: dc.subjecthypertension-
Palavras-chave: dc.subjectnitric oxide-
Palavras-chave: dc.subjectnitrite-
Palavras-chave: dc.subjectpharmacogenetics-
Palavras-chave: dc.subjectpreeclampsia-
Título: dc.titleARG2 single-nucleotide polymorphism rs3742879 affects plasma arginase 2 levels, nitric oxide formation and antihypertensive therapy response in preeclampsia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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