Polymorphisms in risk genes of type 2 diabetes mellitus could be also markers of susceptibility to periodontitis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUnion of the Colleges of the Great Lakes (UNILAGO)-
Autor(es): dc.contributorUniversity Center of the Associated Faculties-
Autor(es): dc.contributorUniversity of North Carolina at Chapel Hill - UNC-
Autor(es): dc.creatorSilva, Arles Naisa Amaral-
Autor(es): dc.creatorNicchio, Ingra Gagno-
Autor(es): dc.creatorda Silva, Bárbara Roque-
Autor(es): dc.creatorMartelli, Maurício Gandini Giani-
Autor(es): dc.creatorHidalgo, Marco A. Rimachi-
Autor(es): dc.creatorNepomuceno, Rafael-
Autor(es): dc.creatorTheodoro, Letícia H.-
Autor(es): dc.creatorCirelli, Joni A.-
Autor(es): dc.creatorOrrico, Silvana R.P.-
Autor(es): dc.creatorCirelli, Thamiris-
Autor(es): dc.creatorBarros, Silvana P.-
Autor(es): dc.creatorScarel-Caminaga, Raquel M.-
Data de aceite: dc.date.accessioned2025-08-21T18:39:46Z-
Data de disponibilização: dc.date.available2025-08-21T18:39:46Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2022.105529-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241576-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241576-
Descrição: dc.descriptionObjectives: This study aimed to investigate polymorphisms in genes considered molecular biomarkers of type 2 diabetes mellitus (T2DM) to assess whether they are associated with periodontitis, and relating them to the periodontal status, glycemic and lipid profile of the subjects. Design: We investigated individuals who underwent complete periodontal examination and biochemical evaluation. We categorized them into three groups: (i) periodontitis with T2DM (Periodontitis+T2DM group, n = 206); (ii) periodontitis without T2DM (Periodontitis group, n = 346); and (iii) healthy individuals without Periodontitis or T2DM (Healthy group, n = 345). We investigated three single nucleotide polymorphisms (SNPs) for AGER, RBMS1 and VEGFA genes. We applied multivariate logistic and multiple linear regression models for all groups and stratified the subjects by sex and smoking habits. Results: Compared with RBMS1-rs7593730-CC+CT genotype carriers, RBMS1-rs7593730-TT carriers were more susceptible to periodontitis [odds ratio (OR) = 2.29; 95% confidence interval (CI) = 1.04–5.01; P-value = 0.033]. Among AGER-rs184003-CC carriers, never smokers had reduced risks of periodontitis and Periodontitis+T2DM than ever smokers. For either RBMS1-rs7593730-CC or VEGFA-rs9472138-CC carriers, never smokers had less susceptibility to develop periodontitis than ever smokers. Compared with AGER-rs184003-CC carriers, AGER-rs184003-AA carriers presented fewer remaining teeth. VEGFA-rs9472138-TT carriers showed a lower percentage of sites with characteristics of active periodontal disease (bleeding on pocket probing and interproximal clinical attachment level) compared with VEGFA-rs9472138-CC carriers. Conclusions: In the studied population, AGER rs184003, RBMS1 rs7593730, and VEGFA rs9472138, which are considered genetic markers for T2DM, were associated with periodontitis without T2DM or periodontitis together with T2DM.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araraquara, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara São Paulo State University - UNESP, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araçatuba, SP-
Descrição: dc.descriptionAdvanced Research Center in Medicine Union of the Colleges of the Great Lakes (UNILAGO), SP-
Descrição: dc.descriptionDepartment of Dentistry University Center of the Associated Faculties, SP-
Descrição: dc.descriptionDepartment of Comprehensive Oral Health - Periodontology School of Dentistry University of North Carolina at Chapel Hill - UNC-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araraquara, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara São Paulo State University - UNESP, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araçatuba, SP-
Descrição: dc.descriptionFAPESP: 2014/13295-1-
Descrição: dc.descriptionFAPESP: 2016/03753-8-
Descrição: dc.descriptionFAPESP: 2016/08070-6-
Descrição: dc.descriptionFAPESP: 2016/18313-3-
Descrição: dc.descriptionCNPq: 304570/2017-6-
Descrição: dc.descriptionCNPq: 306073/2020-0-
Descrição: dc.descriptionCNPq: 445336/2014-5-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiomarker-
Palavras-chave: dc.subjectDiabetes mellitus-
Palavras-chave: dc.subjectGenetic-
Palavras-chave: dc.subjectGWAS-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectPolymorphism-
Título: dc.titlePolymorphisms in risk genes of type 2 diabetes mellitus could be also markers of susceptibility to periodontitis-
Tipo de arquivo: dc.typelivro digital-
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