EGFL7 expression profile in IDH-wildtype glioblastomas is associated with poor patient outcome

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.contributorDr. Paulo Prata - FACISB-
Autor(es): dc.contributorOhio State University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.contributorICVS/3B's - PT Government Associate Laboratory-
Autor(es): dc.creatorDa Costa, Bruno Henrique Bressan-
Autor(es): dc.creatorBecker, Aline Paixao-
Autor(es): dc.creatorNeder, Luciano-
Autor(es): dc.creatorGoncalves, Paola Gyuliane-
Autor(es): dc.creatorDe Oliveira, Cristiane-
Autor(es): dc.creatorPolverini, Allan Dias-
Autor(es): dc.creatorClara, Carlos Afonso-
Autor(es): dc.creatorTeixeira, Gustavo Ramos-
Autor(es): dc.creatorReis, Rui Manuel-
Autor(es): dc.creatorBidinotto, Lucas Tadeu-
Data de aceite: dc.date.accessioned2025-08-21T16:23:15Z-
Data de disponibilização: dc.date.available2025-08-21T16:23:15Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4132/jptm.2022.04.22-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241570-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241570-
Descrição: dc.descriptionBackground: Despite the advances in glioblastoma (GBM) treatment, the average life span of patients is 14 months. Therefore, it is urgent to identity biomarkers of prognosis, treatment response, or development of novel treatment strategies. We previously described the association of high epidermal growth factor-like domain multiple 7 (EGFL7) expression and unfavorable outcome of pilocytic astrocytoma patients. The present study aims to analyze the prognostic potential of EGFL7 in GBM isocitrate dehydrogenase (IDH)-wildtype, using immunohistochemistry and in silico approaches. Methods: Spearman's correlation analysis of The Cancer Genome Atlas RNA sequencing data was performed. The genes strongly correlated to EGFL7 expression were submitted to enrichment gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Additionally, EGFL7 expression was associated with patient overall survival. The expression of EGFL7 was analyzed through immunohistochemistry in 74 GBM IDH-wildtype patients' samples, and was associated with clinicopathological data and overall survival. Results: In silico analysis found 78 genes strongly correlated to EGFL7 expression. These genes were enriched in 40 biological processes and eight KEGG pathways, including angiogenesis/vasculogenesis, cell adhesion, and phosphoinositide 3-kinase-Akt, Notch, and Rap1 signaling pathways. The immunostaining showed high EGFL7 expression in 39 cases (52.7%). High immunolabelling was significantly associated with low Karnofsky Performance Status and poor overall survival. Cox analysis showed that GBMs IDH-wildtype with high EGFL7 expression presented a higher risk of death compared to low expression (hazard ratio, 1.645; 95% confidence interval, 1.021 to 2.650; p = .041). Conclusions: This study gives insights regarding the genes that are correlated with EGFL7, as well as biological processes and signaling pathways, which should be further investigated in order to elucidate their role in glioblastoma biology.-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital, Barretos-
Descrição: dc.descriptionBarretos School of Health Sciences Dr. Paulo Prata - FACISB, Barretos-
Descrição: dc.descriptionOhio State University Department of Radiation Oncology-
Descrição: dc.descriptionDepartment of Pathology School of Medicine of Ribeirao Preto University of Sao Paulo, Ribeirao Preto-
Descrição: dc.descriptionUNESP - Univ. Estadual Paulista School of Medicine Department of Pathology, Botucatu-
Descrição: dc.descriptionDepartment of Neurosurgery Barretos Cancer Hospital, Barretos-
Descrição: dc.descriptionDepartment of Pathology Barretos Cancer Hospital, Barretos-
Descrição: dc.descriptionLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho-
Descrição: dc.descriptionICVS/3B's - PT Government Associate Laboratory, Guimaraes-
Descrição: dc.descriptionUNESP - Univ. Estadual Paulista School of Medicine Department of Pathology, Botucatu-
Formato: dc.format205-211-
Idioma: dc.languageen-
Relação: dc.relationJournal of Pathology and Translational Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEGFL7-
Palavras-chave: dc.subjectGlioblastoma IDH-wildtype-
Palavras-chave: dc.subjectNotch pathway-
Palavras-chave: dc.subjectPI3K-Akt pathway-
Palavras-chave: dc.subjectRap1 pathway-
Título: dc.titleEGFL7 expression profile in IDH-wildtype glioblastomas is associated with poor patient outcome-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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