Doxycycline Attenuates Doxorubicin-Induced Cardiotoxicity by Improving Myocardial Energy Metabolism in Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDantas, Danielle-
Autor(es): dc.creatorPereira, Amanda Gomes-
Autor(es): dc.creatorFujimori, Anderson Seiji Soares-
Autor(es): dc.creatorRibeiro, Ana Paula Dantas-
Autor(es): dc.creatorde Almeida Silva, Carol Cristina Vágula-
Autor(es): dc.creatorMonte, Marina Gaiato-
Autor(es): dc.creatorCorrêa, Camila Renata-
Autor(es): dc.creatorFernandes, Ana Angélica-
Autor(es): dc.creatorBazan, Silmeia Garcia Zanati-
Autor(es): dc.creatorAzevedo, Paula Schmidt-
Autor(es): dc.creatorMinicucci, Marcos Ferreira-
Autor(es): dc.creatorde Paiva, Sergio Alberto Rupp-
Autor(es): dc.creatorZornoff, Leonardo Antônio Mamede-
Autor(es): dc.creatorPolegato, Bertha Furlan-
Data de aceite: dc.date.accessioned2025-08-21T22:34:56Z-
Data de disponibilização: dc.date.available2025-08-21T22:34:56Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jcdd9080254-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241563-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241563-
Descrição: dc.descriptionAim: Evaluate the influence of doxycycline, an anti-inflammatory and matrix metalloproteinase (MMP) inhibitor, on the attenuation of chronic doxorubicin-induced cardiotoxicity in rats. Methods: We allocated male Wistar rats into four groups: control (C), doxorubicin (D), doxycycline (inhibitor of MMP, IM), and Dox + doxycycline (DIM). Groups IM and DIM received doxycycline (5 mg/kg, IP) once a week for 4 weeks. In addition, 48 h after every doxycycline injection, groups D and DIM received Dox (5 mg/kg, IP). We performed echocardiogram and evaluated TIMP-4 and collagen I protein expression, MMP-2 activity, and oxidative stress and myocardial metabolism. Results: Doxorubicin promotes left atrium (LA) and left ventricle (LV) dilatation and decreases in LV fractional shortening, which was improved by doxycycline. Moreover, doxycycline attenuated the LV cardiomyocyte hypertrophy and collagen type I expression. Doxorubicin increased phosphofructokinase and decreased beta-hydroxyacyl Co-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, and ATP synthase activity, which was partially attenuated by doxycycline. Lastly, doxycycline improved antioxidant enzyme activity in the DIM group. Conclusion: Doxorubicin increases oxidative stress and promotes changes in myocardial energy metabolism, accompanied by structural and functional changes. Doxycycline attenuated the doxorubicin-induced cardiotoxicity, at least in part, through changes in myocardial energy metabolism.-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry Institute of Biosciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cardiovascular Development and Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcollagen I-
Palavras-chave: dc.subjectdoxycycline-
Palavras-chave: dc.subjectMMP-2-
Palavras-chave: dc.subjectmyocardial energy metabolism-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectTIMP-4-
Título: dc.titleDoxycycline Attenuates Doxorubicin-Induced Cardiotoxicity by Improving Myocardial Energy Metabolism in Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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