Electrospun polylactic acid scaffolds with strontium- and cobalt-doped bioglass for potential use in bone tissue engineering applications

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPraça Marechal Eduardo Gomes-
Autor(es): dc.creatorde Souza, Joyce Rodrigues-
Autor(es): dc.creatorKukulka, Elisa Camargo-
Autor(es): dc.creatorAraújo, Juliani Caroline Ribeiro-
Autor(es): dc.creatorCampos, Tiago Moreira Bastos-
Autor(es): dc.creatordo Prado, Renata Falchete-
Autor(es): dc.creatorde Vasconcellos, Luana Marotta Reis-
Autor(es): dc.creatorThin, Gilmar Patrocínio-
Autor(es): dc.creatorBorges, Alexandre Luiz Souto-
Data de aceite: dc.date.accessioned2025-08-21T19:44:04Z-
Data de disponibilização: dc.date.available2025-08-21T19:44:04Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jbm.b.35141-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241500-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241500-
Descrição: dc.descriptionThe development of nanoscale biomaterials associated with polymers has been growing over the years, due to their important structural characteristics for applications in biological systems. The present study aimed to produce and test polymeric scaffolds composed of polylactic acid (PLA) fibers associated with a 58S bioglass doped with therapeutic ions for use in tissue engineering. Three 58S Bioglass was obtained by the sol–gel route, pure and doped with 5% strontium and cobalt ions. Solutions of 7% PLA was used as control and added the three different bioglass, 4% of 58S bioglass (PLA-BG), 4% bioglass-doped strontium (PLA-BGSr) and 4% bioglass-doped cobalt (PLA-BGCo). Scaffolds were produced through electrospinning process, and was characterized chemical and morphologically. The in vitro tests were performed using mesenchymal cells cultures from femurs of nine rats, grown in osteogenic supplemented total culture medium. After osteoblastic differentiation induction cell viability, alkaline phosphatase activity, total protein content quantification, and visualization of mineralization nodule tests were performed. Analysis of normal distribution used the Shapiro–Wilk test (nanofibers diameter and biological assay). Data were compared using the Kruskal–Wallis nonparametric test (p = 0.05). The bioglasses produced proved to be free of nitrate, chlorinated and nano-sized, with effective incorporation of therapeutic ions in their structure. All materials showed cell viability (>70%), total protein production, and alkaline phosphatase activity. It was possible to develop polylactic acid scaffolds associated with 58S bioglass doped with therapeutic ions without cytotoxicity. Scaffolds characteristics appear to sustain its application in bone tissue engineering.-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP) Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionTechnological Institute of Aeronautics (ITA) Praça Marechal Eduardo Gomes, São Paulo-
Descrição: dc.descriptionDepartment of Social Dentistry and Children's Clinic Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP) Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Social Dentistry and Children's Clinic Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Biomedical Materials Research - Part B Applied Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbioglass-
Palavras-chave: dc.subjectbiopolymers-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectcobalt-
Palavras-chave: dc.subjectpolylactic acid-
Palavras-chave: dc.subjectstrontium-
Palavras-chave: dc.subjecttissue engineering-
Título: dc.titleElectrospun polylactic acid scaffolds with strontium- and cobalt-doped bioglass for potential use in bone tissue engineering applications-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.