Effects of ultra-low dose hormone therapy on biochemical bone turnover markers in postmenopausal women: A randomized, placebo-controlled, double-blind trial

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorFederal University of Rio Grande do Sul–UFRGS-
Autor(es): dc.contributorJundiai School of Medicine-
Autor(es): dc.contributorABC School of Medicine-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPaulista Center for Clinical Research-CEPIC-
Autor(es): dc.contributorPUC-RS-
Autor(es): dc.contributorLibbs Farmacêutica Ltda-
Autor(es): dc.creatorCosta-Paiva, Lucia-
Autor(es): dc.creatorO Wender, Maria Celeste-
Autor(es): dc.creatorMachado, Rogerio B-
Autor(es): dc.creatorPompei, Luciano M-
Autor(es): dc.creatorNahas, Eliana A-
Autor(es): dc.creatorNahas-Neto, Jorge-
Autor(es): dc.creatorDel Debbio, Sonia Y-
Autor(es): dc.creatorBadalotti, Mariangela-
Autor(es): dc.creatorCruz, Achilles M-
Data de aceite: dc.date.accessioned2025-08-21T19:48:39Z-
Data de disponibilização: dc.date.available2025-08-21T19:48:39Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/20533691221116769-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241483-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241483-
Descrição: dc.descriptionObjective: Evaluate the effects of ultra-low-dose hormone therapy (Ultra-LD HT) with 17β-estradiol 0.5 mg and norethisterone acetate 0.1 mg (E2 0.5/NETA 0.1) versus placebo on bone turnover markers (BTM) in postmenopausal women. Study Design: A multicenter, double-blind, randomized, placebo-controlled study was performed with 107 participants who received one tablet daily of E2 0.5/NETA 0.1 or placebo for 24-weeks. Bone formation markers-N-terminal propeptide of type I procollagen (PINP) and Bone-specific alkaline phosphatase (BSAP), and bone resorption markers-C-telopeptide of type I collagen (CTX-I) and N-telopeptide crosslinked of type I collagen (NTX) were assessed before and at 12 and 24-weeks of treatment. Results: Women treated with E2 0.5/NETA 0.1 had a significant reduction in the PINP marker from baseline (58.49 ± 21.12 μg/L) to week 12 (48.31 ± 20.99 μg/L) and week 24 (39.16 ± 16.50 μg/L). Placebo group, the PINP marker did not differ significantly. The analysis of the BSAP indicated a significant increase in the placebo group (13.8 ± 5.09 μg/L and 16.29 ± 4.3 μg/L, at baseline and week 24, respectively), whereas in the treatment group the values did not change. The analysis of the NTX marker showed a significant reduction only in the treatment group (43.21 ± 15.26 nM/mM and 33.89 ± 14.9 nM/mM, at baseline and week 24, respectively). CTX-I had a significant decrease in the treatment group from baseline (0.3 ± 0.16 ng/L) to week 12 (0.21 ± 0.14 ng/L) and week 24 (0.21 ± 0.12 ng/L). Conclusion: Women receiving E2 0.5/NETA 0.1 experienced reductions in bone resorption and formation markers, an expected effect during the anti-resorptive therapy, suggesting a protective bone effect with the Ultra-LD HT.-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Faculty of Medical Sciences State University of Campinas-UNICAMP Campinas-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Federal University of Rio Grande do Sul–UFRGS-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Jundiai School of Medicine-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics ABC School of Medicine-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu School of Medicine UNESP-Sao Paulo State University-
Descrição: dc.descriptionPaulista Center for Clinical Research-CEPIC-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics PUC-RS-
Descrição: dc.descriptionDepartment of Clinical Research Libbs Farmacêutica Ltda-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu School of Medicine UNESP-Sao Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationPost Reproductive Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbone mineral density-
Palavras-chave: dc.subjectbone turnover marker-
Palavras-chave: dc.subjectestrogen-
Palavras-chave: dc.subjectmenopause-
Palavras-chave: dc.subjectultra-low-dose hormone therapy-
Título: dc.titleEffects of ultra-low dose hormone therapy on biochemical bone turnover markers in postmenopausal women: A randomized, placebo-controlled, double-blind trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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