Head circumference as an epigenetic risk factor for maternal nutrition

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMEAC–Maternity School of the Federal University of Ceara-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorFederal University of Rio Grande do Sul-
Autor(es): dc.contributorJundiaí School of Medicine-
Autor(es): dc.contributorKings College London-
Autor(es): dc.creatorMiele, Maria J.-
Autor(es): dc.creatorSouza, Renato T.-
Autor(es): dc.creatorCalderon, Iracema M.-
Autor(es): dc.creatorFeitosa, Francisco E.-
Autor(es): dc.creatorLeite, Debora F.-
Autor(es): dc.creatorRocha Filho, Edilberto A.-
Autor(es): dc.creatorVettorazzi, Janete-
Autor(es): dc.creatorMayrink, Jussara-
Autor(es): dc.creatorFernandes, Karayna G.-
Autor(es): dc.creatorVieira, Matias C.-
Autor(es): dc.creatorPacagnella, Rodolfo C.-
Autor(es): dc.creatorCecatti, Jose G.-
Data de aceite: dc.date.accessioned2025-08-21T18:06:57Z-
Data de disponibilização: dc.date.available2025-08-21T18:06:57Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-18-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fnut.2022.867727-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241476-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241476-
Descrição: dc.descriptionNutrition indicators for malnutrition can be screened by many signs such as stunting, underweight or obesity, muscle wasting, and low caloric and nutrients intake. Those deficiencies are also associated with low socioeconomic status. Anthropometry can assess nutritional status by maternal weight measurements during pregnancy. However, most studies have focused primarily on identifying changes in weight or Body Mass Index (BMI), and their effects on neonatal measures at present time. Whereas head circumference (HC) has been associated with nutrition in the past. When the mother was exposed to poor nutrition and unfavorable social conditions during fetal life, it was hypothesized that the intergenerational cycle was potentially mediated by epigenetic mechanisms. To investigate this theory, maternal head circumference (MHC) was associated with neonatal head circumference (NHC) in pregnant women without preexisting chronic conditions, differentiated by sociodemographic characteristics. A multiple linear regression model showed that each 1 cm-increase in MHC correlated with a 0.11 cm increase in NHC (β95% CI 0.07 to 0.15). Notwithstanding, associations between maternal and neonatal anthropometrics according to gestational age at birth have been extensively explained. Path analysis showed the influence of social status and the latent variable was socioeconomic status. A model of maternal height and head circumference was tested with effects on neonatal HC. The social variable lacked significance to predict neonatal HC in the total sample (p = 0.212) and in the South/Southeast (p = 0.095), in contrast to the Northeast (p = 0.047). This study highlights the potential intergenerational influence of maternal nutrition on HC, suggesting that maternal nutrition may be more relevant in families with major social vulnerability.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionBill and Melinda Gates Foundation-
Descrição: dc.descriptionDepartment of Obstetrics and Gynaecology University of Campinas (UNICAMP) School of Medicine, SP-
Descrição: dc.descriptionDepartment of Gynaecology and Obstetrics Botucatu Medical School São Paulo State University (Unesp), SP-
Descrição: dc.descriptionMEAC–Maternity School of the Federal University of Ceara, CE-
Descrição: dc.descriptionDepartment of Gynaecology and Obstetrics Federal University of Pernambuco, PE-
Descrição: dc.descriptionDepartment of Obstetrics and Gynaecology Maternity Hospital Federal University of Rio Grande do Sul, RS-
Descrição: dc.descriptionDepartment of Obstetrics and Gynaecology Jundiaí School of Medicine, SP-
Descrição: dc.descriptionDivision of Women and Children's Health School of Life Course Sciences Faculty of Life Sciences and Medicine Kings College London-
Descrição: dc.descriptionDepartment of Gynaecology and Obstetrics Botucatu Medical School São Paulo State University (Unesp), SP-
Descrição: dc.descriptionCNPq: 401636/2013-5-
Descrição: dc.descriptionBill and Melinda Gates Foundation: OPP1107597-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Nutrition-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanthropometry-
Palavras-chave: dc.subjectmaternal nutrition-
Palavras-chave: dc.subjectnewborn-
Palavras-chave: dc.subjectpregnancy-
Palavras-chave: dc.subjectsocioeconomic factors-
Título: dc.titleHead circumference as an epigenetic risk factor for maternal nutrition-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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