Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.creatorReis, Ana Carolina Casali-
Autor(es): dc.creatorJorge, Bárbara Campos-
Autor(es): dc.creatorPaschoalini, Beatriz Rizzo-
Autor(es): dc.creatorBueno, Jéssica Nogueira-
Autor(es): dc.creatorStein, Julia-
Autor(es): dc.creatorMoreira, Suyane da Silva-
Autor(es): dc.creatorManoel, Beatriz de Manoel-
Autor(es): dc.creatorFernandes, Glaura Scantamburlo Alves-
Autor(es): dc.creatorHisano, Hamilton-
Autor(es): dc.creatorArena, Arielle Cristina-
Data de aceite: dc.date.accessioned2025-08-21T17:42:46Z-
Data de disponibilização: dc.date.available2025-08-21T17:42:46Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/01480545.2022.2105864-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241444-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241444-
Descrição: dc.descriptionSince studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista–Botucatu (UNESP)-
Descrição: dc.descriptionDepartment of General Biology Biological Sciences Center State University of Londrina–UEL-
Descrição: dc.descriptionEmbrapa Environment-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista–Botucatu (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista–Botucatu (UNESP)-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista–Botucatu (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationDrug and Chemical Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbenzo(a)pyrene-
Palavras-chave: dc.subjectendocrine disruptor-
Palavras-chave: dc.subjectfemale fertility-
Palavras-chave: dc.subjectjuvenile period-
Palavras-chave: dc.subjectPolycyclic aromatic hydrocarbon-
Palavras-chave: dc.subjectpuberty-
Palavras-chave: dc.subjectrats-
Título: dc.titleLong-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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