RIP2 Contributes to Expanded CD4+ T Cell IFN-g Production during Efferocytosis of Streptococcus pneumoniae–Infected Apoptotic Cells

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad del Cauca-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Paraíba-
Autor(es): dc.contributorVanderbilt University Medical Center-
Autor(es): dc.creatorNiño-Castaño, Victoria Eugenia-
Autor(es): dc.creatorde Aquino Penteado, Letícia-
Autor(es): dc.creatorSilva-Pereira, Ludmilla-
Autor(es): dc.creatorBazzano, Júlia Miranda Ribeiro-
Autor(es): dc.creatorOrlando, Allan Botinhon-
Autor(es): dc.creatorSalina, Ana Carolina Guerta-
Autor(es): dc.creatorDejani, Naiara Naiana-
Autor(es): dc.creatorBonato, Vânia L.D.-
Autor(es): dc.creatorSerezani, C. Henrique-
Autor(es): dc.creatorMedeiros, Alexandra Ivo-
Data de aceite: dc.date.accessioned2025-08-21T18:07:51Z-
Data de disponibilização: dc.date.available2025-08-21T18:07:51Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4049/immunohorizons.2200001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241434-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241434-
Descrição: dc.descriptionApoptotic cell clearance by professional and nonprofessional phagocytes in the process of efferocytosis is critical to preserve tissue homeostasis. Uptake of apoptotic cells by dendritic cells generates regulatory T cells and induces immunologic tolerance against self-antigens. In contrast, ingestion of infected apoptotic cells promotes activation of TLR4/MyD88-dependent bone marrow–derived dendritic cells (BMDCs) and triggers Th17 cell differentiation. In this study, we evaluated the impact of Streptococcus pneumoniae–infected apoptotic cell efferocytosis by BMDCs derived from C57BL/6 mice on differentiation and expansion of CD4+ T cell subsets, as well as the role of TLR2/4 and receptor-interacting protein 2 (RIP2) receptors in recognizing intracellular pathogens during efferocytosis. We demonstrated that BMDC-mediated efferocytosis of S. pneumoniae–infected apoptotic cells induced Th1 cell differentiation and expansion. Although TLR2/4 and RIP2 deficiency in BMDCs did not affect Th1 cell differentiation during efferocytosis, the absence of RIP2 decreased IFN-γ production by CD4 T cells during the expansion phase. These findings suggest that RIP2-mediated IL-1β production during efferocytosis of S. pneumoniae–infected apoptotic cells partially supports a Th1-mediated IFN-γ production microenvironment.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University, Sao Paulo-
Descrição: dc.descriptionDepartment of Pathology Faculty of Health Science Universidad del Cauca, Cauca-
Descrição: dc.descriptionBasic and Applied Immunology Program Ribeirao Preto Medical SchoolUniversity of Sao Paulo-
Descrição: dc.descriptionDepartment of Physiology and Pathology Federal University of Paraíba, Paraíba-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Medicine Division of Infectious Diseases Vanderbilt University Medical Center-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University, Sao Paulo-
Descrição: dc.descriptionFAPESP: 11/17611-7-
Descrição: dc.descriptionFAPESP: 12/23580-0-
Descrição: dc.descriptionFAPESP: 16/10964-5-
Descrição: dc.descriptionFAPESP: 17/04786-0-
Descrição: dc.descriptionFAPESP: 17/21629--
Descrição: dc.descriptionFAPESP: 18/19638-9-
Descrição: dc.descriptionFAPESP: 20/ 09327-6-
Descrição: dc.descriptionCNPq: 306363/2013-5-
Descrição: dc.descriptionCNPq: 307109/2016-0-
Descrição: dc.descriptionCNPq: 471945/2012-9-
Formato: dc.format559-568-
Idioma: dc.languageen-
Relação: dc.relationImmunoHorizons-
???dc.source???: dc.sourceScopus-
Título: dc.titleRIP2 Contributes to Expanded CD4+ T Cell IFN-g Production during Efferocytosis of Streptococcus pneumoniae–Infected Apoptotic Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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