Fluoride and trimetaphosphate association as a novel approach for remineralization and antiproteolytic activity in dentin tissue

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Ribeirão Preto - UNAERP-
Autor(es): dc.creatorNunes, Gabriel Pereira-
Autor(es): dc.creatorDanelon, Marcelle-
Autor(es): dc.creatorPessan, Juliano Pelim-
Autor(es): dc.creatorCapalbo, Letícia Cabrera-
Autor(es): dc.creatorJunior, Nilson Antônio Nunes-
Autor(es): dc.creatorMatos, Adriana Arruda-
Autor(es): dc.creatorSouza, José Antonio Santos-
Autor(es): dc.creatorBuzalaf, Marília Afonso Rabelo-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Data de aceite: dc.date.accessioned2025-08-21T18:57:43Z-
Data de disponibilização: dc.date.available2025-08-21T18:57:43Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2022.105508-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241417-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241417-
Descrição: dc.descriptionObjective: The study evaluated the effect of solutions containing fluoride (F) and/or sodium trimetaphosphate (TMP) and F/TMP on the inhibition of MMP-2 and MMP-9, and on dentin remineralization in vitro. Design: Bovine root dentin blocks were prepared, and caries-like lesions were induced in two thirds of the surface. Blocks were then randomly divided into 13 groups/solutions (n = 10): Placebo; 0.3 %, 1 % and 3 % NaOH-hydrolyzed TMP; 0.3 %, 1 % and 3 % TMP; 250, 500 and 1100 ppm F; 250 ppm F + 0.3 % TMP; 500 ppm F + 1 % TMP and 1100 ppm F + 3 % TMP. One third of each specimen was treated with the respective solutions in pH-cycling. The mineral concentration (gHAp × cm−3 × µm) was determined by computed X-ray microtomography, and data submitted to ANOVA and Student-Newman-Keuls’ test (p < 0.05). The ability of the solutions to inhibit MMP-2 and MMP-9 activity was assessed by zymography. Results: F/TMP association led to less mineral loss in the deeper region of the lesion and reduced the depth of lesions when compared to its counterpart without TMP (p < 0.001). 3 % TMP (hydrolyzed or not), 500 ppm F and 1100 ppm F completely inhibited MMP-2 activity, while for MMP-9 such effects were only achieved by treatment with 1100 ppm F + 3 % TMP. Conclusion: Treatment with 1100 ppm F + 3 % TMP fully inhibits the gelatinolytic activity of MMPs-2 and − 9 and shows greater remineralizing capacity in artificial caries lesions in dentin. However, hydrolyzing TMP does not improve its anti-proteolytic activity and its remineralizing capacity.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Preventive and Restorative Dentistry-
Descrição: dc.descriptionSchool of Dentistry University of Ribeirão Preto - UNAERP-
Descrição: dc.descriptionSão Paulo State University (USP) School of Dentistry Bauru Department of Biological Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Preventive and Restorative Dentistry-
Descrição: dc.descriptionSão Paulo State University (USP) School of Dentistry Bauru Department of Biological Sciences-
Descrição: dc.descriptionFAPESP: #2018/19505-9-
Descrição: dc.descriptionCAPES: PROCAD/2013 - 88881.068437/2014–2001-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDentin-
Palavras-chave: dc.subjectFluoride-
Palavras-chave: dc.subjectMatrix metalloproteinases-
Palavras-chave: dc.subjectPhosphate-
Palavras-chave: dc.subjectRemineralization-
Título: dc.titleFluoride and trimetaphosphate association as a novel approach for remineralization and antiproteolytic activity in dentin tissue-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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