Solid dipersions included in poloxamer hydrogels have favorable rheological properties for topical application and enhance the in vivo antiinflammatory effect of ursolic acid

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Valencia-
Autor(es): dc.contributorFederal University of Ceara-
Autor(es): dc.creatorPironi, Andressa Maria-
Autor(es): dc.creatorMelero, Ana-
Autor(es): dc.creatorEloy, Josimar O.-
Autor(es): dc.creatorGuillot, Antonio José-
Autor(es): dc.creatorPini Santos, Kaio-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T22:05:33Z-
Data de disponibilização: dc.date.available2025-08-21T22:05:33Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jddst.2022.103602-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241406-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241406-
Descrição: dc.descriptionUrsolic acid (UA) solid dispersions (SD) formulated into poloxamer-hydrogels were prepared for local treatment of skin inflammations. The hydrogel physico-chemical properties were evaluated, including rheology, in vitro drug permeation and cytotoxicity. The anti-inflammatory activity of the systems was investigated using the animal model of croton oil-induced ear edema. The formulations demonstrated a pseudoplastic behavior and elastic properties (G’ > G”). SDs in hydrogels demonstrated less resistance to flow, an increase in the sol-gel transition temperature and a decrease in G′ followed by an increase in G″ when compared to the hydrogel obtained only in NaCl solution. Bioadhesion and texture properties proved the formulations were suitable for topical application. Hydrogels controlled the diffusion process of the drug within the polymeric network, due to the higher viscosity of this systems. The permeability studies showed that the formulations composed of D-α-tocopheryl polyethylene glycol 1000 succinate provided greater UA diffusion through the skin. The anti-inflammatory effect of UA-SDs was significantly improved when formulated in poloxamer hydrogels, with the ability to inhibit 41.87% and 56.64% of edema when compared to the group of animals that did not receive treatment (negative control). These results indicate the advantages of UA-loaded SDs incorporated into hydrogel for topical treatment of inflammatory skin disorders.-
Descrição: dc.descriptionUniversitat de València-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Drugs and Medicines São Paulo State University School of Pharmaceutical Sciences, Araraquara-
Descrição: dc.descriptionDepartament of Pharmacy and Pharmaceutical Technology and Parasitology University of Valencia-
Descrição: dc.descriptionDepartment of Pharmacy Federal University of Ceara, Fortaleza-
Descrição: dc.descriptionDepartment of Drugs and Medicines São Paulo State University School of Pharmaceutical Sciences, Araraquara-
Descrição: dc.descriptionFAPESP: 2016/22544-0-
Descrição: dc.descriptionFAPESP: 2018/17768-2-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Delivery Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectPoloxamer-hydrogel-
Palavras-chave: dc.subjectSkin disorders-
Palavras-chave: dc.subjectSolid dispersion-
Palavras-chave: dc.subjectUrsolic acid-
Título: dc.titleSolid dipersions included in poloxamer hydrogels have favorable rheological properties for topical application and enhance the in vivo antiinflammatory effect of ursolic acid-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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