Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorYamamoto, Priscila Akemi-
Autor(es): dc.creatorBenzi, Jhohann Richard de Lima-
Autor(es): dc.creatorDach, Fabíola-
Autor(es): dc.creatorde Moraes, Natália Valadares-
Data de aceite: dc.date.accessioned2025-08-21T21:18:20Z-
Data de disponibilização: dc.date.available2025-08-21T21:18:20Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s2175-97902022e191073-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241378-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241378-
Descrição: dc.descriptionGabapentin is an antiepileptic drug prescribed for several neuropathic pain conditions. This study aimed to evaluate gabapentin (GAB) trough plasma concentration range and the applicability of therapeutic drug monitoring in patients with neuropathic pain. Fifty-three patients with neuropathic pain, aged 20 to 75, received gabapentin as treatment for at least 7 days. Gabapentin plasma concentration was sampled before GAB administration and quantified by liquid chromatography with a UV detector. GAB trough plasma concentration ranged between 0.40 and 11.94 µg/mL in patients with chronic neuropathic pain. No differences were observed in terms of GAB plasma concentrations between responsive and non-responsive patients. Our data suggest that the reference ranges suggested in the literature for patients with epilepsy should not be used for patients with neuropathic pain. Therapeutic drug monitoring of GAB was shown to be an important tool to assess treatment adherence.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Neurosciences and Behavioral Sciences Ribeirão Preto Medical School University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Pharmaceutical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGabapentin-
Palavras-chave: dc.subjectNeuropathic pain-
Palavras-chave: dc.subjectTherapeutic drug monitoring-
Título: dc.titleTherapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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