Potential Anticarcinogenic Effects From Plasma of Older Adults After Exercise Training: An Exploratory Study

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Autor(es): dc.contributorUniversidade Federal de Ciências da Saúde de Porto Alegre-
Autor(es): dc.contributorUniversidade Federal de Ciências da Saúde de Porto Alegre—UFCSPA-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Coimbra-
Autor(es): dc.contributorUniversidade Federal do Rio Grande do Sul-
Autor(es): dc.creatorPeres, Alessandra-
Autor(es): dc.creatorBranchini, Gisele-
Autor(es): dc.creatorMarmett, Bruna-
Autor(es): dc.creatorNunes, Fernanda Bordignon-
Autor(es): dc.creatorRomão, Pedro R.T.-
Autor(es): dc.creatorOlean-Oliveira, Tiago-
Autor(es): dc.creatorMinuzzi, Luciele-
Autor(es): dc.creatorCavalcante, Mateus-
Autor(es): dc.creatorElsner, Viviane-
Autor(es): dc.creatorLira, Fabio Santos-
Autor(es): dc.creatorDorneles, Gilson Pires-
Data de aceite: dc.date.accessioned2025-08-21T15:50:28Z-
Data de disponibilização: dc.date.available2025-08-21T15:50:28Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2022.855133-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241377-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241377-
Descrição: dc.descriptionAim: To evaluate the impact of exercise training plasma on in vitro prostate cancer cell viability and proliferation. Methods: PC3 prostate cancer cells were incubated with plasma obtained from young men with high and low physical fitness (PF) (high PF, n = 5; low PF, n = 5) and with the plasma collected from institutionalized older adults (n = 8) before and after multimodal exercise training. Cell viability and proliferation, mitochondria membrane polarization, reactive oxygen species (ROS) generation, and apoptosis were evaluated after the cell treatment with plasma. Systemic cytokines were evaluated in the plasma of institutionalized older adults submitted to an exercise training protocol. Results: Plasma from high-PF men lowers both cell viability and proliferation after the incubation time. PC3 cells also presented lower cell viability and diminished rates of cell proliferation after the incubation with post-training plasma samples of the older adults. The incubation of PC3 cells with post-training plasma of older adults depolarized the mitochondrial membrane potential and increased mitochondrial reactive oxygen species production. Post-training plasma did not change apoptosis or necrosis rates in the PC3 cell line. Multimodal exercise training increased the plasma levels of IL-2, IL-10, IFN-α, and FGF-1 and decreased TNF-α concentrations in institutionalized older adults. Conclusion: Adaptations in blood factors of institutionalized older adults may alter cell viability and proliferation by targeting mitochondrial ROS in a prostate cancer cell line.-
Descrição: dc.descriptionLaboratório de Imunologia Celular e Molecular Departamento de Ciências Básicas da Saúde Universidade Federal de Ciências da Saúde de Porto Alegre-
Descrição: dc.descriptionPrograma de Pós-graduação em Patologia Universidade Federal de Ciências da Saúde de Porto Alegre—UFCSPA-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP), Presidente Prudente-
Descrição: dc.descriptionFaculty of Sports Science and Physical Education Research Center for Sports and Physical Activity University of Coimbra-
Descrição: dc.descriptionPrograma de Pós-graduação em Fisiologia Universidade Federal do Rio Grande do Sul-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP), Presidente Prudente-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaging-
Palavras-chave: dc.subjectexercise training-
Palavras-chave: dc.subjectimmune response-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmitochondria-
Palavras-chave: dc.subjectprostate cancer-
Título: dc.titlePotential Anticarcinogenic Effects From Plasma of Older Adults After Exercise Training: An Exploratory Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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