Is micronucleus assay in oral exfoliated cells a useful biomarker for biomonitoring populations exposed to pesticides? A systematic review with meta-analysis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMalacarne, Ingra Tais-
Autor(es): dc.creatorTakeshita, Wilton Mitsunari-
Autor(es): dc.creatorde Souza, Daniel Vitor-
Autor(es): dc.creatordos Anjos Rosario, Barbara-
Autor(es): dc.creatorde Barros Viana, Milena-
Autor(es): dc.creatorRenno, Ana Claudia Muniz-
Autor(es): dc.creatorSalvadori, Daisy Maria Favero-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Data de aceite: dc.date.accessioned2025-08-21T21:23:54Z-
Data de disponibilização: dc.date.available2025-08-21T21:23:54Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11356-022-22015-x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241367-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241367-
Descrição: dc.descriptionThe systematic review (SR) with meta-analysis aimed to infer if micronucleus assay using oral mucosal cells a useful biomarker for biomonitoring populations continuously exposed to pesticides (EP). The SR has been made in accordance with the PRISMA-P guidelines. The PICOS strategy has focused to answer the following question: “Does exposure to pesticides cause genetic damage in oral cells?” The literature search was made in the following scientific databases: Web of Science, PubMed/Medline, and Scopus. The approach was defined as follows: standardized mean difference (SMD) and 95% confidence intervals (CI). The quality assessment of manuscripts was obtained by the EPHPP (Effective Public Health Practice Project). The GRADE tool was chosen for assessing the quality of evidence. A total of 108 articles were selected in this setting. After screening abstracts and titles, 23 manuscripts were evaluated for eligibility. After reviewing the studies, two were considered weak and 22 were classified as moderate or strong. The meta-analysis data pointed out statistically significant differences in volunteers exposed to EP (SMD = 1.23, 95% CI, 0.69 to 1.77, p < 0.001), with a Tau2 = 1.44; Chi2 = 566.38, and p < 0.001, so that the selected manuscripts were considered heterogeneous and the I2 of 97% indicated high heterogeneity. Taken together, this review was able to validate the micronucleus assay in oral exfoliated cells as a useful biomarker in individuals continuously exposed to EP because the studies categorized as moderate and strong have demonstrated positive response related to mutagenesis.-
Descrição: dc.descriptionDepartment of Biosciences Institute of Health and Society Federal University of São Paulo UNIFESP Rua Silva Jardim, 136, Room 332, Vila Mathias, SP-
Descrição: dc.descriptionDepartment of Dentistry Federal University of Sergipe UFS, SE-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University UNESP, SP-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Science and Pollution Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGenetic damage-
Palavras-chave: dc.subjectMicronucleus assay-
Palavras-chave: dc.subjectOral mucosa-
Palavras-chave: dc.subjectPesticide-
Título: dc.titleIs micronucleus assay in oral exfoliated cells a useful biomarker for biomonitoring populations exposed to pesticides? A systematic review with meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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