Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSão José Dos Campos-
Autor(es): dc.creatorMarques Meccatti, Vanessa-
Autor(es): dc.creatorDe Souza Moura, Larissa-
Autor(es): dc.creatorGuerra Pinto, Juliana-
Autor(es): dc.creatorFerreira-Strixino, Juliana-
Autor(es): dc.creatorAbu Hasna, Amjad-
Autor(es): dc.creatorAlves Figueiredo-Godoi, Lívia Mara-
Autor(es): dc.creatorCampos Junqueira, Juliana-
Autor(es): dc.creatorMarcucci, Maria Cristina-
Autor(es): dc.creatorPaula Ramos, Lucas De-
Autor(es): dc.creatorCarvalho, Claudio Antonio Talge-
Autor(es): dc.creatorPucci, Cesar Rogério-
Autor(es): dc.creatorDe Oliveira, Luciane Dias-
Data de aceite: dc.date.accessioned2025-08-21T20:51:08Z-
Data de disponibilização: dc.date.available2025-08-21T20:51:08Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2022/5837864-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241335-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241335-
Descrição: dc.descriptionRadiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes LEDon Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.-
Descrição: dc.descriptionDepartment Of Biosciences And Oral Diagnosis Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos Campos-
Descrição: dc.descriptionPhotobiology Applied To Health (PHOTOBIOS)-University Of Vale Do Paraiba Research And Development Institute São José Dos Campos, Av. Shishima Hifumi, 2911-
Descrição: dc.descriptionDepartment Of Restorative Dentistry Endodontics Division Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos Campos-
Descrição: dc.descriptionDepartment Of Restorative Dentistry Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos Campos-
Descrição: dc.descriptionDepartment Of Biosciences And Oral Diagnosis Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos Campos-
Descrição: dc.descriptionDepartment Of Restorative Dentistry Endodontics Division Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos Campos-
Descrição: dc.descriptionDepartment Of Restorative Dentistry Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos Campos-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Dentistry-
???dc.source???: dc.sourceScopus-
Título: dc.titleCurcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo-
Tipo de arquivo: dc.typelivro digital-
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