Clinical Presentation, Treatment Outcomes, and Resistance-related Factors in South American Women with Low-risk Postmolar Gestational Trophoblastic Neoplasia

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad de Caldas-
Autor(es): dc.contributorUniversidad de Buenos Aires-
Autor(es): dc.contributorOncólogos Del Occidente S.A. Manizales-
Autor(es): dc.contributorUniversidad Central de Venezuela-
Autor(es): dc.contributorHarvard Medical School-
Autor(es): dc.contributorImperial College Healthcare NHS Trust-
Autor(es): dc.creatorRamírez, Luz Angela Correa-
Autor(es): dc.creatorMaestá, Izildinha-
Autor(es): dc.creatorBianconi, María Inés-
Autor(es): dc.creatorJankilevich, Gustavo-
Autor(es): dc.creatorOtero, Silvina-
Autor(es): dc.creatorMejía, Carlos Raúl Villegas-
Autor(es): dc.creatorCortés-Charry, Rafael-
Autor(es): dc.creatorElias, Kevin M.-
Autor(es): dc.creatorHorowitz, Neil S.-
Autor(es): dc.creatorSeckl, Michael-
Autor(es): dc.creatorBerkowitz, Ross S.-
Data de aceite: dc.date.accessioned2025-08-21T20:42:00Z-
Data de disponibilização: dc.date.available2025-08-21T20:42:00Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1055/s-0042-1748974-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241328-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241328-
Descrição: dc.descriptionObjective â There are few multinational studies on gestational trophoblastic neoplasia (GTN) treatment outcomes in South America. The purpose of this study was to assess the clinical presentation, treatment outcomes, and factors associated with chemoresistance in low-risk postmolar GTN treated with first-line single-Agent chemotherapy in three South American centers. Methods â Multicentric, historical cohort study including women with International Federation of Gynecology and Obstetrics (FIGO)-staged low-risk postmolar GTN attending centers in Argentina, Brazil, and Colombia between 1990 and 2014. Data were obtained on patient characteristics, disease presentation, and treatment response. Logistic regression was used to assess the relationship between clinical factors and resistance to first-line single-Agent treatment. A multivariate analysis of the clinical factors significant in univariate analysis was performed. Results â A total of 163 women with low-risk GTN were included in the analysis. The overall rate of complete response to first-line chemotherapy was 80% (130/163). The rates of complete response to methotrexate or actinomycin-D as first-line treatment, and actinomycin-D as second-line treatment postmethotrexate failure were 79% (125/157), 83% (â š), and 70% (23/33), respectively. Switching to second-line treatment due to chemoresistance occurred in 20.2% of cases (33/163). The multivariate analysis demonstrated that patients with a 5 to 6 FIGO risk score were 4.2-fold more likely to develop resistance to first-line single-Agent treatment (p = 0.019). Conclusion â 1) At presentation, most women showed clinical characteristics favorable to a good outcome, 2) the overall rate of sustained complete remission after first-line single-Agent treatment was comparable to that observed in developed countries, 3) a FIGO risk score of 5 or 6 is associated with development of resistance to first-line single-Agent chemotherapy.-
Descrição: dc.descriptionTocogynecology of Botucatu Medical School São Paulo State University Julio de Mesquita Filho UNESP Support Program for Foreign Doctoral Students (PAEDEx/UNESP)-
Descrição: dc.descriptionClinical Department Universidad de Caldas-
Descrição: dc.descriptionBotucatu Trophoblastic Disease Center of the Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics São Paulo State University Julio de Mesquita Filho UNESP-
Descrição: dc.descriptionCarlos G Durand Hospital Trophoblastic Disease Center Faculty of Medicine Universidad de Buenos Aires-
Descrição: dc.descriptionOncólogos Del Occidente S.A. Manizales-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Hospital Universitario de Caracas Universidad Central de Venezuela-
Descrição: dc.descriptionDivision of Gynecologic Oncology Department of Obstetrics Harvard Medical School-
Descrição: dc.descriptionTrophoblastic Tumour Screening and Treatment Centre Charing Cross Hospital Imperial College Healthcare NHS Trust-
Descrição: dc.descriptionTocogynecology of Botucatu Medical School São Paulo State University Julio de Mesquita Filho UNESP Support Program for Foreign Doctoral Students (PAEDEx/UNESP)-
Descrição: dc.descriptionBotucatu Trophoblastic Disease Center of the Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics São Paulo State University Julio de Mesquita Filho UNESP-
Idioma: dc.languageen-
Relação: dc.relationRevista Brasileira de Ginecologia e Obstetricia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchemotherapy-
Palavras-chave: dc.subjectlow-risk gestational trophoblastic neoplasia-
Palavras-chave: dc.subjectmolar pregnancy-
Palavras-chave: dc.subjectresistance-related factors-
Palavras-chave: dc.subjectSouth America-
Título: dc.titleClinical Presentation, Treatment Outcomes, and Resistance-related Factors in South American Women with Low-risk Postmolar Gestational Trophoblastic Neoplasia-
Título: dc.titleApresentação clínica, resultados do tratamento e fatores relacionados à resistência em mulheres sul-Americanas com neoplasia trofoblástica gestacional pós-molar de baixo risco-
Tipo de arquivo: dc.typelivro digital-
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