Two-year risedronate treatment for osteoporosis in patients with esophageal varices: a non-randomized clinical trial

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGeneral Hospital of Shenyang Military Command-
Autor(es): dc.creatorSantos, Lívia Alves Amaral-
Autor(es): dc.creatorLima, Talles Bazeia-
Autor(es): dc.creatorde Carvalho Nunes, Hélio Rubens-
Autor(es): dc.creatorQi, Xingshun-
Autor(es): dc.creatorRomeiro, Fernando Gomes-
Data de aceite: dc.date.accessioned2025-08-21T19:51:45Z-
Data de disponibilização: dc.date.available2025-08-21T19:51:45Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12072-022-10366-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241256-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241256-
Descrição: dc.descriptionBackground: Bisphosphonates are the mainstay of osteoporosis treatment, but their use for patients with esophageal varices has been avoided due to the risk of esophagitis, which may cause variceal bleeding. Since most clinical trials assessing osteoporosis treatment last 2–3 years, this study aimed to evaluate a 2-year risedronate treatment for patients with esophageal varices and liver cirrhosis. Methods: The study received Institutional Review Board approval, and the sample was divided into two groups according to bone mineral density (BMD). Cirrhosis severity and endoscopic findings at baseline were similar between the groups. The intervention group had 51 patients with osteoporosis, who received oral risedronate 35 mg weekly plus calcium and vitamin D supplements. The control group had 51 patients with osteopenia, receiving only the supplements. Scheduled esophagogastroduodenoscopies and BMD measurements were carried out. Results: The adjusted esophagitis risk was higher in the intervention group; however, none of the subjects had digestive bleeding. Lumbar spine BMD increased in the intervention group (− 3.06 ± 0.71 to − 2.33 ± 0.90; p < 0.001) and in the control group (− 1.38 ± 0.77 to − 1.10 ± 1.05; p = 0.012). Femoral neck BMD did not change in the intervention group (− 1.64 ± 0.91 to − 1.71 ± 0.95; p = 0.220), but tended to decrease in the control group (− 1.00 ± 0.74 to − 1.09 ± 0.82; p = 0.053). Conclusion: Oral risedronate was effective and did not cause gastrointestinal bleeding in cirrhotic patients with esophageal varices under endoscopic surveillance. Graphic abstract: [Figure not available: see fulltext.]-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Gastroenterology Division-São Paulo State University (UNESP), Rubião Júnior s/n, SP-
Descrição: dc.descriptionPublic Health Department Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionGeneral Hospital of Shenyang Military Command, Sheng-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Gastroenterology Division-São Paulo State University (UNESP), Rubião Júnior s/n, SP-
Descrição: dc.descriptionPublic Health Department Botucatu Medical School São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationHepatology International-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBisphosphonates-
Palavras-chave: dc.subjectBone mineral density-
Palavras-chave: dc.subjectCirrhosis-
Palavras-chave: dc.subjectDual-energy X-ray absorptiometry-
Palavras-chave: dc.subjectEndoscopy-
Palavras-chave: dc.subjectEsophageal varices-
Palavras-chave: dc.subjectEsophagitis-
Palavras-chave: dc.subjectGastrointestinal hemorrhage-
Palavras-chave: dc.subjectOsteopenia-
Palavras-chave: dc.subjectOsteoporosis-
Título: dc.titleTwo-year risedronate treatment for osteoporosis in patients with esophageal varices: a non-randomized clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.