Transcranial doppler as screening method for sickling crises in children with sickle cell anemia: a latin America cohort study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal Do Triângulo Mineiro (UFTM)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorModolo, Gabriel Pinheiro-
Autor(es): dc.creatorLuvizutto, Gustavo José-
Autor(es): dc.creatorHamamoto Filho, Pedro Tadao-
Autor(es): dc.creatorBraga, Gabriel Pereira-
Autor(es): dc.creatorBazan, Silmeia Garcia Zanati-
Autor(es): dc.creatorFerreira, Natalia Cristina-
Autor(es): dc.creatorde Souza, Juli Thomaz-
Autor(es): dc.creatorWinckler, Fernanda Cristina-
Autor(es): dc.creatorMacedo de Freitas, Carlos Clayton-
Autor(es): dc.creatorHokama, Newton Key-
Autor(es): dc.creatorVidal, Edison Iglesias de Oliveira-
Autor(es): dc.creatorBazan, Rodrigo-
Data de aceite: dc.date.accessioned2025-08-21T20:26:36Z-
Data de disponibilização: dc.date.available2025-08-21T20:26:36Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12887-022-03429-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241243-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241243-
Descrição: dc.descriptionBackground: Sickle cell anemia (SCA) is the leading cause of childhood stroke. We aimed to evaluate whether altered cerebral flow velocities, as measured by transcranial Doppler (TCD), are associated with vaso-occlusive complications in addition to stroke in pediatric SCA patients. Methods: We evaluated 37 children aged between 2 and 16 years with SCA who underwent screening for TCD between January 2012 and October 2018. Genotypic profiles and demographic data were collected, TCD examinations were performed during follow-up, and the presence of sickling crises was compared. Survival analyses were performed using simple frailty models, in which each predictor variable was analyzed separately in relation to the occurrence of a sickling crisis. Results: The variables related to sickle cell crises in the univariate analysis were peak systolic velocity (PSV) in the middle cerebral artery (MCA), hazard ratio (HR) 1.01 (1.00—1.02) p = 0.04; end-diastolic velocity (EDV) in the MCA, HR 1.02 (1.01—1.04) p = 0.01; time average mean maximum velocity (TAMMV) in the basilar artery (BA), HR 1.02 (1.00—1.04) p = 0.04; hemoglobin, HR 0.49 (0.38—0.65) p < 0.001; hematocrit, HR 0.78 (0.71—0.85) p < 0.001; leukocyte counts, HR 1.1 (1.05—1.15) p < 0.001; platelets counts, HR 0.997 (0.994—0.999) p = 0.02; and reticulocyte numbers, HR 1.14 (1.06—1.23) p < 0.001. Conclusions: Our results indicate PSV and EDV in the MCA and TAMMV in the BA as markers of risk for the occurrence of sickling crises in SCA.-
Descrição: dc.descriptionDepartmento de Neurologia Psicologia e Psiquiatria Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartmento de Fisioterapia Aplicada Universidade Federal Do Triângulo Mineiro (UFTM), Minas Gerais-
Descrição: dc.descriptionFaculdade de Medicina Universidade Federal de Mato Grosso Do Sul (UFMS), Mato Grosso Do Sul-
Descrição: dc.descriptionDepartamento de Clínica Médica Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartmento de Neurologia Psicologia e Psiquiatria Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartamento de Clínica Médica Universidade Estadual Paulista (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationBMC Pediatrics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectSickle cell anemia-
Palavras-chave: dc.subjectStroke-
Palavras-chave: dc.subjectTranscranial Doppler-
Título: dc.titleTranscranial doppler as screening method for sickling crises in children with sickle cell anemia: a latin America cohort study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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