Enzymatic synthesis of geranyl acetate in batch and fed-batch reactors and evaluation of its larvicidal activity against Rhipicephalus (Boophilus) microplus

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.creatorRemonatto, Daniela-
Autor(es): dc.creatorFantatto, Rafaela Regina-
Autor(es): dc.creatorPietro, Rosemeire Cristina Linhari Rodrigues-
Autor(es): dc.creatorMonti, Rubens-
Autor(es): dc.creatorOliveira, J. Vladimir-
Autor(es): dc.creatorde Paula, Ariela Veloso-
Autor(es): dc.creatorBassan, Juliana Cristina-
Data de aceite: dc.date.accessioned2025-08-21T23:19:16Z-
Data de disponibilização: dc.date.available2025-08-21T23:19:16Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.procbio.2022.06.012-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241235-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241235-
Descrição: dc.descriptionGeraniol esters, such as geranyl acetate, are known to have antimicrobial and insect-repellent action, but their acaricidal activity has been little explored. This study aimed to investigate the solvent-free synthesis of geranyl acetate in batch (BSTR) and fed-batch (FBSTR) stirred tank reactors using the immobilized lipases NS 88011 and Novozym 435 and evaluate its larvicidal activity against the cattle tick Rhipicephalus (Boophilus) microplus. A central composite design (CCD) was used to maximize the synthesis of geranyl acetate in a BSTR. The independent variables were temperature reaction (40–60 °C), acetic acid/geraniol molar ratio (1:1–1:3), and enzyme loading (1–5% w/w in relation to the substrates). Novozym 435 yielded the best results, achieving 99% of geranyl acetate conversion using 1:3 acetic acid/geraniol molar ratio, 60 °C and 5% (w/w) of enzyme loading after 1 h of reaction in a BSTR. In the FBSTR system, a high content of geranyl acetate was obtained (about 80%) in 4 h of reaction using a 1:1 acetic acid/geraniol molar ratio, 60 °C and 5% (w/w) Novozym 435. Geranyl acetate showed potential as an acaricide, with an LC90 of 6.25 mg/mL and 100% mortality at a concentration of 12.5 mg/mL.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Bioprocesses and Biotechnology Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Chemical and Food Engineering Federal University of Santa Catarina (UFSC), SC-
Descrição: dc.descriptionDepartment of Bioprocesses and Biotechnology Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2020/09592-1-
Formato: dc.format287-300-
Idioma: dc.languageen-
Relação: dc.relationProcess Biochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEsterification-
Palavras-chave: dc.subjectFed-batch-
Palavras-chave: dc.subjectGeraniol-
Palavras-chave: dc.subjectGeranyl acetate-
Palavras-chave: dc.subjectLarvicidal-
Palavras-chave: dc.subjectLipase-
Título: dc.titleEnzymatic synthesis of geranyl acetate in batch and fed-batch reactors and evaluation of its larvicidal activity against Rhipicephalus (Boophilus) microplus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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