Non-invasive Brain Stimulation Can Reduce Unilateral Spatial Neglect after Stroke: ELETRON Trial

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.contributorFederal University of Triângulo Mineiro (UFTM)-
Autor(es): dc.creatorda Silva, Taís Regina-
Autor(es): dc.creatorde Carvalho Nunes, Hélio Rubens-
Autor(es): dc.creatorMartins, Laís Geronutti-
Autor(es): dc.creatorda Costa, Rafael Dalle Molle-
Autor(es): dc.creatorde Souza, Juli Thomaz-
Autor(es): dc.creatorWinckler, Fernanda Cristina-
Autor(es): dc.creatorSartor, Lorena Cristina Alvarez-
Autor(es): dc.creatorModolo, Gabriel Pinheiro-
Autor(es): dc.creatorFerreira, Natalia Cristina-
Autor(es): dc.creatorda Silva Rodrigues, Josiela Cristina-
Autor(es): dc.creatorKanda, Rafael-
Autor(es): dc.creatorFogarolli, Marcelo Ortolani-
Autor(es): dc.creatorBorges, Guilherme Ferreira-
Autor(es): dc.creatorRizzatti, Gabriela Rizzo Soares-
Autor(es): dc.creatorRibeiro, Priscila Watson-
Autor(es): dc.creatorFavoretto, Diandra B.-
Autor(es): dc.creatordos Santos, Luan R. Aguiar-
Autor(es): dc.creatorBazan, Silméia Garcia Zanati-
Autor(es): dc.creatorBetting, Luiz Eduardo-
Autor(es): dc.creatorde Oliveira Antunes, Leticia Cláudia-
Autor(es): dc.creatorPereira, Vitor Mendes-
Autor(es): dc.creatorEdwards, Taiza G. S.-
Autor(es): dc.creatorPontes-Neto, Octávio Marques-
Autor(es): dc.creatorConforto, Adriana Bastos-
Autor(es): dc.creatorBazan, Rodrigo-
Autor(es): dc.creatorLuvizutto, Gustavo José-
Data de aceite: dc.date.accessioned2025-08-21T21:41:20Z-
Data de disponibilização: dc.date.available2025-08-21T21:41:20Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/ana.26430-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241234-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241234-
Descrição: dc.descriptionObjective: Rehabilitation top-down techniques based on brain stimulation present variable outcomes in unilateral spatial neglect (USN) after stroke. This study aimed to examine the effects of physical therapy after anodal and cathodal transcranial direct current stimulation (A-tDCS and C-tDCS, respectively) to improve visuospatial and functional impairments in individuals with USN after stroke. Methods: This double-blinded, pilot randomized clinical trial enrolled patients with USN after ischemic stroke. Randomization was stratified according to the Behavior Inattention Test–Conventional (BIT-C) and Catherine Bergego Scale (CBS). Outpatient physical therapy was conducted for 7.5 weeks after 20 minutes of tDCS. The primary outcome was the USN degree evaluated by the BIT-C. Secondary outcomes were the difference in CBS score, stroke severity (National Institutes of Health Stroke Scale [NIHSS]), disability (modified Rankin Scale), autonomy (Barthel Index, Functional Independence Measure), and quality of life (EuroQol Group 5-Dimension Self-Report Questionnaire). Outcomes were analyzed using an analysis of covariance model corrected by age, baseline NIHSS, and baseline BIT-C. Pairwise post hoc comparisons were performed using Bonferroni correction. Results: In the primary outcomes, A-tDCS led to greater improvement in BIT-C after intervention (mean difference [MD] = 18.4, 95% confidence interval [CI] = 3.9–32.8, p = 0.008) compared to sham. However, no significant differences were observed between A-tDCS and C-tDCS (MD = 13.9, 95% CI = −0.3 to 28.1, p = 0.057), or C-tDCS and sham (MD = 4.5, 95% CI = −9.7 to 18.8, p = 0.99). There were no significant differences between groups in terms of secondary outcomes. Interpretation: A-tDCS associated with physical therapy can decrease the severity of USN after stroke. However, these preliminary findings must be confirmed by collecting additional evidence in a larger phase 3 trial. ANN NEUROL 2022;92:400–410.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Public Health Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Rehabilitation Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Neurology Department of Psychology and Psychiatry Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Neurosciences and Behavioral Sciences Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionDivision of Neurosurgery Department of Surgery St Michael's Hospital University of Toronto-
Descrição: dc.descriptionClinical Hospital São Paulo University (USP) and Hospital Israelita Albert Einstein-
Descrição: dc.descriptionDepartment of Applied Physical Therapy Federal University of Triângulo Mineiro (UFTM)-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Public Health Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Rehabilitation Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Neurology Department of Psychology and Psychiatry Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2015/14231-0-
Descrição: dc.descriptionCNPq: 423924/2016-8-
Formato: dc.format400-410-
Idioma: dc.languageen-
Relação: dc.relationAnnals of Neurology-
???dc.source???: dc.sourceScopus-
Título: dc.titleNon-invasive Brain Stimulation Can Reduce Unilateral Spatial Neglect after Stroke: ELETRON Trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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