Interleukin-6, tumor necrosis factor-α, and CD5 immunolabeling of new experimental endodontic sealer and repair material

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.creatorBenetti, Francine-
Autor(es): dc.creatorFerreira, Luciana Louzada-
Autor(es): dc.creatorDos Reis-Prado, Alexandre Henrique-
Autor(es): dc.creatorFaria, Flávio Duarte-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorBerbert, Fabio Luiz Camargo Vellela-
Autor(es): dc.creatorLeonardo, Renato de Toledo-
Autor(es): dc.creatorDias, João-
Autor(es): dc.creatorGomes-Filho, João Eduardo-
Autor(es): dc.creatorCintra, Luciano Tavares Angelo-
Data de aceite: dc.date.accessioned2025-08-21T18:52:58Z-
Data de disponibilização: dc.date.available2025-08-21T18:52:58Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10266-022-00723-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241227-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241227-
Descrição: dc.descriptionThe aim of this study was to evaluate the biocompatibility and immunoinflammatory response of the Sealepox and Sealepox-RP, based on interleukin (IL)-6, tumor necrosis factor (TNF)-α, and CD5 immunolabelling. The ProRoot MTA (PRMTA) was used for comparison. Polyethylene tubes (1.0-mm internal, 1.6-mm external diameter, and 10.0-mm length; ISO 10993) with or without (control) materials were randomly implanted in the dorsum of 35 rats (4 per rat). After 7, 15, 30, 60, and 90 days (n = 7), the tubes were removed for histological and immunohistochemical analysis. The Kruskal–Wallis and Dunn’s test for non-parametric data and, ANOVA and Tukey test for parametric data were used (P < 0.05). Hematoxylin and eosin staining revealed that the concentration of inflammatory cells decreased over time with no differences between groups in all periods (P > 0.05). Regarding IL-6 immunostaining, there was no difference at 7 days (P > 0.05); all groups decreased over time, being faster for the PRMTA group and also, with no differences between groups in the last period (P > 0.05). For TNF-α, at 7 days there was no difference between groups (P > 0.05); there was an increase at 15 days for PRMTA and, at 30 and 60 days, for PRMTA and Sealepox compared to the control (P < 0.05). At 90 days, Sealepox RP showed the lowest immunostaining being similar to the control (P > 0.05). Regarding CD5 cells, at 7 days, there was high immunostaining for PRMTA compared to the control (P < 0.05); and significant reduction over time with difference for all groups at 30 and 60 days. (P < 0.05); Sealepox was similar to the control in all periods (P > 0.05). Sealepox RP showed the highest immunostaining at 15 days, being different from the control and PRMTA (P < 0.05); in the other periods it was similar to the control (P > 0.05). It can be concluded that Sealepox and Sealepox-RP were biocompatible and demonstrated similar immunoinflammatory response regarding IL-6, TNF-α, and CD5 compared to PRMTA.-
Descrição: dc.descriptionDepartment of Restorative Dentistry Faculdade de Odontologia Universidade Federal de Minas Gerais (UFMG), MG-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (Unesp), R: José Bonifácio, 1193. Vila Mendonça, São Paulo-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionUniversity Institute Egas Moniz (IUEM), Monte de Caparica-
Descrição: dc.descriptionSchool of Dentistry Dental Assistance Center for Disabled Persons (CAOE) of the São Paulo State University (UNESP), SP-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (Unesp), R: José Bonifácio, 1193. Vila Mendonça, São Paulo-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionSchool of Dentistry Dental Assistance Center for Disabled Persons (CAOE) of the São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationOdontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiocompatibility-
Palavras-chave: dc.subjectExperimental sealers-
Palavras-chave: dc.subjectImmune markers-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectRepair material-
Título: dc.titleInterleukin-6, tumor necrosis factor-α, and CD5 immunolabeling of new experimental endodontic sealer and repair material-
Tipo de arquivo: dc.typelivro digital-
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