Use of the amphotericin B, miconazole, and sodium hypochlorite to control the growth of the robust Aspergillus flavus and Aspergillus fumigatus biofilms on polyethylene support

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFrancisco, Camila Guedes-
Autor(es): dc.creatorBraga, Gilberto Bida Leite-
Autor(es): dc.creatorGuimarães, Luis Henrique Souza-
Data de aceite: dc.date.accessioned2025-08-21T22:03:17Z-
Data de disponibilização: dc.date.available2025-08-21T22:03:17Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.7324/JABB.2022.100404-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241204-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241204-
Descrição: dc.descriptionAspergillus flavus and Aspergillus fumigatus are able to grow on surfaces, including medical equipment, forming robust and resistant biofilms, and protecting the fungal cells against antifungal agents. Based on that, A. flavus and A. fumigatus biofilms were treated for 48 h with amphotericin B, miconazole, and sodium hypochlorite. Amphotericin B and miconazole acted as fungistatic for both fungal strains. The minimal inhibitory concentration for the amphotericin B was 400 µg mL-1 and >833 µg mL-1 for A. flavus and A. fumigatus, respectively, for the miconazole was 600 µg mL-1 and 1200 µg mL-1. Sodium hypochlorite presented fungicide activity at 8.3 µg mL-1 on A. flavus biofilms, while for A. fumigatus biofilm only fungistatic activity was observed. A. flavus biofilms were most susceptive to the treatment with the antifungal agents than were A. fumigatus. Our observation suggests that these robust structures as an interesting model to study fungal resistance.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biochemistry Instituto de Química de Araraquara Universidade Estadual Paulista “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionDepartment of Clinical Analysis Toxicology and Bromatology Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, São Paulo-
Descrição: dc.descriptionDepartment of Biology Faculdade de Filosofia Ciências e Letras de Ribeirão Preto USP, São Paulo-
Descrição: dc.descriptionDepartment of Biochemistry Instituto de Química de Araraquara Universidade Estadual Paulista “Júlio de Mesquita Filho”, São Paulo-
Formato: dc.format27-34-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Biology and Biotechnology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal treatment-
Palavras-chave: dc.subjectAspergillus flavus-
Palavras-chave: dc.subjectAspergillus fumigatus-
Palavras-chave: dc.subjectFungal biofilms-
Palavras-chave: dc.subjectFungal resistance-
Palavras-chave: dc.subjectSodium hypochlorite-
Título: dc.titleUse of the amphotericin B, miconazole, and sodium hypochlorite to control the growth of the robust Aspergillus flavus and Aspergillus fumigatus biofilms on polyethylene support-
Tipo de arquivo: dc.typelivro digital-
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