Impact of glycine and erythritol/chlorhexidine air-polishing powders on human gingival fibroblasts: An in vitro study

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Autor(es): dc.contributorUniversity Medical Center of the Johannes Gutenberg University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Bonn-
Autor(es): dc.creatorWeusmann, Jens-
Autor(es): dc.creatorDeschner, James-
Autor(es): dc.creatorImber, Jean-Claude-
Autor(es): dc.creatorDamanaki, Anna-
Autor(es): dc.creatorCerri, Paulo Sérgio-
Autor(es): dc.creatorLeguizamón, Natalia-
Autor(es): dc.creatorBeisel-Memmert, Svenja-
Autor(es): dc.creatorNogueira, Andressa Vilas Boas-
Data de aceite: dc.date.accessioned2025-08-21T22:04:08Z-
Data de disponibilização: dc.date.available2025-08-21T22:04:08Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.aanat.2022.151949-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241194-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241194-
Descrição: dc.descriptionBACKGROUND: Supra- and subgingival air-polishing has been used in periodontitis and gingivitis therapy for years. Low-abrasive types of powders have facilitated the application in subgingival areas. In this study, the cellular effects of a glycine powder and an erythritol/chlorhexidine (CHX) powder on human gingival fibroblasts (HGF) were investigated. METHODS: HGF were obtained from sound gingiva of three healthy donors. After 12 h and 24 h of incubation time, cell viability testing and, after 24 h and 48 h, a cell proliferation assay was conducted. Additionally, the individual components erythritol and CHX were investigated for cell viability. In vitro wound healing was monitored for 48 h and scanning electron microscopy (SEM) analysis was performed after 24 h. Statistical analysis was accomplished by ANOVA and post hoc Dunnett's and Tukey's tests (p < 0.05) were performed. RESULTS: Erythritol/CHX powder and in a lower extent, glycine powder decreased cell viability and cell proliferation. The negative effect of erythritol/CHX was mainly based on the CHX component. In vitro wound healing was negatively influenced in both types of powders compared to control. Cell size was altered in both test groups, whereas cell morphology was affected only in the erythritol/CHX group. CONCLUSIONS: The investigated powders for subgingival air-polishing can influence cell viability, morphology, and proliferation, as well as wound closure in vitro. These actions on fibroblasts are discernible, with the cytotoxic effect of erythritol/CHX powder being very clear and mainly due to the CHX component. Our results suggest that subgingivally applied powders can exert direct effects on gingival fibroblasts.-
Descrição: dc.descriptionUniversity Medical Center of the Johannes Gutenberg University Department of Periodontology and Operative Dentistry-
Descrição: dc.descriptionUniversity Medical Center of the Johannes Gutenberg University, Department of Periodontology and Operative Dentistry, Mainz, Germany; University of Bern, Department of Periodontology, Bern, Switzerland-
Descrição: dc.descriptionSão Paulo State University School of Dentistry at Araraquara Department of Morphology Genetics Orthodontics and Pediatric Dentistry-
Descrição: dc.descriptionUniversity Medical Center of the Johannes Gutenberg University, Department of Periodontology and Operative Dentistry, Mainz, Germany; São Paulo State University, School of Dentistry at Araraquara, Department of Diagnosis and Surgery, Araraquara, Brazil. Electronic address: natidaponte@gmail.com-
Descrição: dc.descriptionDepartment of Orthodontics Center of Dento-Maxillo-Facial Medicine University of Bonn-
Descrição: dc.descriptionSão Paulo State University School of Dentistry at Araraquara Department of Morphology Genetics Orthodontics and Pediatric Dentistry-
Formato: dc.format151949-
Idioma: dc.languageen-
Relação: dc.relationAnnals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAir polishing-
Palavras-chave: dc.subjectCell biology-
Palavras-chave: dc.subjectChlorhexidine-
Palavras-chave: dc.subjectErythritol-
Palavras-chave: dc.subjectGlycine-
Palavras-chave: dc.subjectPeriodontology-
Título: dc.titleImpact of glycine and erythritol/chlorhexidine air-polishing powders on human gingival fibroblasts: An in vitro study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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