Maternal Diabetes and Postnatal High-Fat Diet on Pregnant Offspring

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.creatorSinzato, Yuri Karen-
Autor(es): dc.creatorPaula, Verônyca Gonçalves-
Autor(es): dc.creatorGallego, Franciane Quintanilha-
Autor(es): dc.creatorMoraes-Souza, Rafaianne Q.-
Autor(es): dc.creatorCorrente, José Eduardo-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Autor(es): dc.creatorDamasceno, Débora Cristina-
Data de aceite: dc.date.accessioned2025-08-21T17:53:19Z-
Data de disponibilização: dc.date.available2025-08-21T17:53:19Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fcell.2022.818621-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241181-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241181-
Descrição: dc.descriptionMaternal diabetes-induced fetal programming predisposes offspring to type 2 diabetes, cardiovascular disease, and obesity in adulthood. However, lifelong health and disease trajectories depend on several factors and nutrition is one of the main ones. We intend to understand the role of maternal diabetes-induced fetal programming and its association with a high-fat diet during lifelong in the female F1 generation focusing on reproductive outcomes and the possible changes in physiological systems during pregnancy as well as the repercussions on the F2 generation at birth. For this, we composed four groups: F1 female pups from control (OC) or from diabetic dams (OD) and fed with standard (SD) or high-fat diet from weaning to full-term pregnancy. During pregnancy, glucose intolerance and insulin sensitivity were evaluated. In a full-term pregnancy, the maternal blood and liver were collected to evaluate redox status markers. The maternal blood, placental tissue, and fetal blood (pool) were collected to evaluate adiponectin and leptin levels. Maternal reproductive parameters were evaluated as well. Maternal diabetes and high-fat diet consumption, in isolation, were both responsible for increased infertility rates and fasting glucose levels in the F1 generation and fetal growth restriction in the F2 generation. The association of both conditions showed, in addition to those, increased lipoperoxidation in maternal erythrocytes, regardless of the increased endogenous antioxidant enzyme activities, glucose intolerance, decreased number of implantation sites and live fetuses, decreased litter, fetal and placental weight, increased preimplantation losses, and increased fetal leptin serum levels. Thus, our findings show that fetal programming caused by maternal diabetes or lifelong high-fat diet consumption leads to similar repercussions in pregnant rats. In addition, the association of both conditions was responsible for glucose intolerance and oxidative stress in the first generation and increased fetal leptin levels in the second generation. Thus, our findings show both the F1 and F2 generations harmed health after maternal hyperglycemic intrauterine environment and exposure to a high-fat diet from weaning until the end of pregnancy.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Cell and Developmental Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdiabetes-
Palavras-chave: dc.subjectFemale reproduction-
Palavras-chave: dc.subjectfetal programming-
Palavras-chave: dc.subjectmalnutrition-
Palavras-chave: dc.subjectrodent-
Título: dc.titleMaternal Diabetes and Postnatal High-Fat Diet on Pregnant Offspring-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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