Effects of Calcium Hydroxide Intracanal Medications on T Helper (Th1, Th2, Th9, Th17, and Tfh) and Regulatory T (Treg) Cell Cytokines in Apical Periodontitis: A CONSORT RCT

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAarhus University-
Autor(es): dc.contributorUniversity of Maryland-
Autor(es): dc.creatorTeixeira, Flavia F.C.-
Autor(es): dc.creatorCardoso, Flavia G.R.-
Autor(es): dc.creatorFerreira, Nadia S.-
Autor(es): dc.creatorCorazza, Bruna J.M.-
Autor(es): dc.creatorValera, Marcia M.C.-
Autor(es): dc.creatorNascimento, Gustavo G.-
Autor(es): dc.creatorMartinho, Frederico C.-
Data de aceite: dc.date.accessioned2025-08-21T16:30:37Z-
Data de disponibilização: dc.date.available2025-08-21T16:30:37Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.joen.2022.04.010-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241152-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241152-
Descrição: dc.descriptionIntroduction: This Consolidated Standards of Reporting Trials randomized clinical trial investigated T helper (Th1, Th2, Th9, Th17, and Tfh) and regulatory T (Treg) cell–type cytokines and their networks in apical periodontitis (AP). We also assessed the effects of calcium hydroxide [Ca(OH)2] intracanal medications (ICMs) on helper T and Treg cell–type cytokines. Methods: Twenty teeth with primary endodontic infection and apical periodontitis were randomly divided into two groups: Ca(OH)2 + saline solution (n = 10) and Ca (OH)2 + 2% chlorhexidine-gel (n = 10). Samples were collected from the periradicular tissue fluid (PTF) before (PTFs1) and after 14 days of ICMs (PTFs2). The Human High Sensitivity T Cell Panel was used to quantify target T-helper (Th)1: interelukin (IL)-2, IL-12, and interferon-gamma (IFN-γ); Th2: IL-4, IL-5, and IL-13; Th9: IL-9; Th17: IL-17; T follicular helper cells (Tfh): IL-21; and Treg-cell-type cytokine: IL-10. Results: Th1-type cytokines were higher than Th2-type ones, at PTFs1. Positive (+) associations were found among all Th1-type cytokines and all Th2-type cytokines. There were negative (-) correlations between all Th1- and Th2-type cytokines. Size of radiolucent lesions and symptoms (tenderness to percussion and/or pain on palpation) were positively correlated with Th1-type cytokines, IL-17, and IL-21 but negatively correlated with Th2-type cytokines and IL-10 (all, P <.001). Both ICMs increased Th2-type cytokines and IL-10 (P <.05) and decreased Th1-type cytokines, IL-17, and IL-21 (P <.05), with no differences among them (P >.05). Conclusions: Complex T-cell cytokine networks are involved in AP. Both Ca(OH)2 ICMs effectively increased IL-4, IL-5, IL-10, and IL-13 and lowered IL-2, IL-12, IL-17, IL-21, and IFN-γ.-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontic Division São Paulo State University–UNESP Institute of Science and Technology São José dos Campos-
Descrição: dc.descriptionDepartment of Dentistry and Oral Health Section for Periodontology Aarhus University-
Descrição: dc.descriptionDepartment of Advanced Oral Sciences and Therapeutics School of Dentistry University of Maryland-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontic Division São Paulo State University–UNESP Institute of Science and Technology São José dos Campos-
Formato: dc.format975-984-
Idioma: dc.languageen-
Relação: dc.relationJournal of Endodontics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectendodontics-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectintracanal medication-
Palavras-chave: dc.subjectroot canal-
Palavras-chave: dc.subjectT-helper-
Título: dc.titleEffects of Calcium Hydroxide Intracanal Medications on T Helper (Th1, Th2, Th9, Th17, and Tfh) and Regulatory T (Treg) Cell Cytokines in Apical Periodontitis: A CONSORT RCT-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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