Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorAbud, Gabriela Ferreira-
Autor(es): dc.creatorDe Carvalho, Flavia Giolo-
Autor(es): dc.creatorBatitucci, Gabriela-
Autor(es): dc.creatorTravieso, Sofia Germano-
Autor(es): dc.creatorBueno Junior, Carlos Roberto-
Autor(es): dc.creatorBarbosa Junior, Fernando-
Autor(es): dc.creatorMarchini, Julio Sergio-
Autor(es): dc.creatorde Freitas, Ellen Cristini-
Data de aceite: dc.date.accessioned2025-08-21T15:21:52Z-
Data de disponibilização: dc.date.available2025-08-21T15:21:52Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.nut.2022.111706-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241141-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241141-
Descrição: dc.descriptionObjective: Based on the antioxidant effects of taurine, which are capable of controlling oxidative stress in the aging process, the aim of this study was to investigate the effects of taurine supplementation on biomarkers of oxidative stress in women 55 to 70 y of age. Methods: A double-blind study was conducted with 24 women (61.4 ± 4.2 y, body mass index 31.4 ± 5.1 kg/m²). The participants were randomly assigned to either a control group (GC, n = 11), supplemented with placebo (1.5 g of starch); or a taurine group (GTAU, n = 13), supplemented with taurine (1.5 g), for 16 wk. As primary outcomes, taurine and oxidative stress marker levels were determined in plasma samples. Anthropometry, functional capacity testing, and plasma mineral levels were evaluated as secondary outcomes. The evaluations were performed pre- and postintervention. Food consumption was assessed before, during, and after the intervention. The results were analyzed by two-way repeated analysis of variance measures mixed model, with the Sidak post hoc (P < 0.05). Results: Taurine and superoxide dismutase (SOD, antioxidant enzyme) plasma levels were increased in the GTAU group. SOD levels also were higher than in the GC group after supplementation. Glutathione reductase levels decreased regardless of the intervention. Malondialdehyde levels increased only in the GC participants. Conclusion: Taurine supplementation prevented the decrease in the antioxidant enzyme SOD, suggesting taurine as a strategy to control oxidative stress during the aging process.-
Descrição: dc.descriptionDepartment of Food and Nutrition School of Pharmaceutical Sciences of Araraquara State University of Sao Paulo – FCF UNESP, Sao Paulo-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirao Preto University of Sao Paulo –EEFERP USP, Sao Paulo-
Descrição: dc.descriptionDepartment of Health Sciences Ribeirao Preto Medical School University of Sao Paulo – FMRP USP, Sao Paulo-
Descrição: dc.descriptionDepartment of Clinical Toxicologic and Bromatological Analysis College of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo – FCFRP USP, Sao Paulo-
Descrição: dc.descriptionInternal Medicine Department Ribeirao Preto Medical School University of Sao Paulo – FMRP USP, São Paulo-
Descrição: dc.descriptionDepartment of Food and Nutrition School of Pharmaceutical Sciences of Araraquara State University of Sao Paulo – FCF UNESP, Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationNutrition-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectNutritional supplementation-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectTaurine-
Palavras-chave: dc.subjectTherapeutic strategy-
Título: dc.titleTaurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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