Sex differences in IL-10’s anti-inflammatory function: Greater STAT3 phosphorylation and stronger inhibition of TNF-α production in male blood leukocytes ex vivo

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Autor(es): dc.contributorUniversity of British Columbia Okanagan-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of British Columbia-
Autor(es): dc.creatorIslam, Hashim-
Autor(es): dc.creatorJackson, Garett S.-
Autor(es): dc.creatorYoon, Jeff S.J.-
Autor(es): dc.creatorCabral-Santos, Carolina-
Autor(es): dc.creatorLira, Fábio S.-
Autor(es): dc.creatorMui, Alice L.-
Autor(es): dc.creatorLittle, Jonathan P.-
Data de aceite: dc.date.accessioned2025-08-21T17:34:16Z-
Data de disponibilização: dc.date.available2025-08-21T17:34:16Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1152/AJPCELL.00091.2022-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241097-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241097-
Descrição: dc.descriptionInterleukin-10 (IL-10) inhibits pro-inflammatory cytokine production in blood leukocytes – an effect mediated by signal transducer and activator of transcription 3 (STAT3) activation. To examine potential sex-based differences in IL-10’s anti-inflammatory function, we treated whole blood from healthy males and females (n=16 each; age: 28±6 years; body mass index: 23.5±2.3 kg/m2) with increasing concentrations of IL-10 (1-100 ng/mL) and quantified changes in phosphorylated STAT3 (pSTAT3) in CD14+ monocytes and CD4+ lymphocytes via flow cytometry. In parallel, liposaccharide (LPS)-stimulated whole-blood cultures were used to assess sex-based differences in IL-10’s ability to inhibit tumour necrosis factor (TNF)-α production. IL-10 concentration-dependently increased pSTAT3 mean fluorescent intensity (MFI) in CD14+ and CD4+ cells (main effects of concentration, P<0.01) with males exhibiting larger changes in pSTAT3 MFI in both cell types (main effects of sex, P<0.01). Accordingly, IL-10-mediated inhibition of TNF-α production was more pronounced in males (main effect of sex, P<0.01) with changes in other monocyte-derived cytokines (IL-1β, IL-1RA, IL-15) also supporting a sexual dimorphism in IL-10 action (P<0.05). These sex-based differences were not explained by differences in circulating plasma IL-10 concentrations, basal IL-10 receptor expression in unstimulated CD14+ and CD4+ cells, nor the basal expression of IL-10 signaling proteins (STAT3, SHIP1, p38 MAPK) in unstimulated peripheral blood mononuclear cells. We conclude that IL-10’s anti-inflammatory function differs between male and female blood leukocytes ex vivo. This sexual dimorphism should be considered in future work investigating IL-10’s anti-inflammatory action in humans as it may represent a mechanism contributing to sex differences in overall immune function.-
Descrição: dc.descriptionSchool of Health and Exercise Sciences University of British Columbia Okanagan-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education Post-Graduation Program in Movement Sciences State University of São Paulo (UNESP), Presidente Prudente-
Descrição: dc.descriptionDepartment of Surgery University of British Columbia-
Descrição: dc.descriptionDepartment of Biochemistry and Molecular Biology University of British Columbia-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education Post-Graduation Program in Movement Sciences State University of São Paulo (UNESP), Presidente Prudente-
Formato: dc.formatC1095-C1104-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Physiology - Cell Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytokine synthesis inhibitory factor-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectlymphocytes-
Palavras-chave: dc.subjectmonocytes-
Palavras-chave: dc.subjectSHIP1-
Palavras-chave: dc.subjectTLR4-
Título: dc.titleSex differences in IL-10’s anti-inflammatory function: Greater STAT3 phosphorylation and stronger inhibition of TNF-α production in male blood leukocytes ex vivo-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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