Anti-TNF therapy for ulcerative colitis in Brazil: a comparative real-world national retrospective multicentric study from the Brazilian study group of IBD (GEDIIB)

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorHospital de Clínicas de Porto Alegre-
Autor(es): dc.contributorFederal University of Rio Grande Do Norte-
Autor(es): dc.contributorMedical School of the Federal University of the Minas Gerais-
Autor(es): dc.contributorCatholic University or Paraná PUCPR-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorFederal University of Alagoas-
Autor(es): dc.contributorUniversidade Do Oeste de Santa Catarina UNOESC-
Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.contributorFundação Universidade de Pernambuco-
Autor(es): dc.contributorHospital de Clínicas de Passo Fundo-
Autor(es): dc.contributorHospital Universitario Getulio Vargas-
Autor(es): dc.contributorGastroclinica Cascavel-
Autor(es): dc.contributorFaculty of Medicine of São José do Rio Preto-
Autor(es): dc.contributorSETE - Specialized Medical Center-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorFaculdade de Medicina do ABC-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorHospital Doutor Dório Silva-
Autor(es): dc.contributorGastromed-
Autor(es): dc.contributorGastroSaude Clinic-
Autor(es): dc.contributorHospital Copa D’Or-
Autor(es): dc.contributorBahia State University UNEB-
Autor(es): dc.contributorFederal University of Piaui-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorSassaki, Ligia Yukie-
Autor(es): dc.creatorMagro, Daniela Oliveira-
Autor(es): dc.creatorSaad-Hossne, Rogerio-
Autor(es): dc.creatorBaima, Julio Pinheiro-
Autor(es): dc.creatorFlores, Cristina-
Autor(es): dc.creatorCorreia, Lucianna Motta-
Autor(es): dc.creatorCelani, Lívia Medeiros Soares-
Autor(es): dc.creatorDe Abreu Ferrari, Maria De Lourdes-
Autor(es): dc.creatorZacharias, Patricia-
Autor(es): dc.creatorFeitosa, Marley Ribeiro-
Autor(es): dc.creatorDos Santos, Carlos Henrique Marques-
Autor(es): dc.creatorDe Freitas Lins Neto, Manoel Alvaro-
Autor(es): dc.creatorQuaresma, Abel Botelho-
Autor(es): dc.creatorDe Lima Junior, Sergio Figueiredo-
Autor(es): dc.creatorDe Vasconcelos, Graciana Bandeira Salgado-
Autor(es): dc.creatorCassol, Ornella Sari-
Autor(es): dc.creatorDos Santos Pinto, Arlene-
Autor(es): dc.creatorKurachi, Gustavo-
Autor(es): dc.creatorGoncalves Filho, Francisco de Assis-
Autor(es): dc.creatorGasparini, Rodrigo Galhardi-
Autor(es): dc.creatorFurlan, Thaísa Kowalski-
Autor(es): dc.creatorCatapani, Wilson Roberto-
Autor(es): dc.creatorCoy, Cláudio Saddy Rodrigues-
Autor(es): dc.creatorDe Souza Menegassi, Vivian-
Autor(es): dc.creatorColombo, Marilia Majeski-
Autor(es): dc.creatorFróes, Renata de Sá Brito-
Autor(es): dc.creatorTeixeira, Fabio Vieira-
Autor(es): dc.creatorMoraes, Antonio Carlos-
Autor(es): dc.creatorSantana, Genoile Oliveira-
Autor(es): dc.creatorParente, José Miguel Luz-
Autor(es): dc.creatorVilela, Eduardo Garcia-
Autor(es): dc.creatorQueiroz, Natália Sousa Freitas-
Autor(es): dc.creatorKotze, Paulo Gustavo-
Data de aceite: dc.date.accessioned2025-08-21T21:31:43Z-
Data de disponibilização: dc.date.available2025-08-21T21:31:43Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12876-022-02341-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241093-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241093-
Descrição: dc.descriptionBackground: Anti-TNF therapy represented a landmark in medical treatment of ulcerative colitis (UC). There is lack of data on the efficacy and safety of these agents in Brazilian patients. The present study aimed to analyze rates of clinical and endoscopic remission comparatively, between adalimumab (ADA) and infliximab (IFX), in Brazilian patients with UC, and evaluate factors associated with clinical and endoscopic remission after 1 year of treatment. Methods: A national retrospective multicenter study (24 centers) was performed including patients with UC treated with anti-TNF therapy. Outcomes as clinical response and remission, endoscopic remission and secondary loss of response were measured in different time points of the follow-up. Baseline predictive factors of clinical and endoscopic remission at week 52 were evaluated using logistic regression model. Indirect comparisons among groups (ADA and IFX) were performed using Student's t, Pearson χ2 or Fisher's exact test when appropriated, and Kaplan Meier analysis. Results: Overall, 393 patients were included (ADA, n = 111; IFX, n = 282). The mean age was 41.86 ± 13.60 years, 61.58% were female, most patients had extensive colitis (62.40%) and 19.39% had previous exposure to a biological agent. Overall, clinical remission rate was 66.78%, 71.62% and 82.82% at weeks 8, 26 and 52, respectively. Remission rates were higher in the IFX group at weeks 26 (75.12% vs. 62.65%, p < 0.0001) and 52 (65.24% vs. 51.35%, p < 0.0001) when compared to ADA. According to Kaplan–Meier survival curve loss of response was less frequent in the Infliximab compared to Adalimumab group (p = 0.001). Overall, endoscopic remission was observed in 50% of patients at week 26 and in 65.98% at week 52, with no difference between the groups (p = 0.114). Colectomy was performed in 23 patients (5.99%). Age, non-prior exposure to biological therapy, use of IFX and endoscopic remission at week 26 were associated with clinical remission after 52 weeks. Variables associated with endoscopic remission were non-prior exposure to biological therapy, and clinical and endoscopic remission at week 26. Conclusions: IFX was associated with higher rates of clinical remission after 1 year in comparison to ADA. Non-prior exposure to biological therapy and early response to anti-TNF treatment were associated with higher rates of clinical and endoscopic remission.-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionColorectal Surgery Unit University of Campinas UNICAMP-
Descrição: dc.descriptionDepartment of Surgery Medical School São Paulo State University Unesp-
Descrição: dc.descriptionHospital de Clínicas de Porto Alegre-
Descrição: dc.descriptionOnofre Lopes Universitary Hospital Federal University of Rio Grande Do Norte-
Descrição: dc.descriptionMedical School of the Federal University of the Minas Gerais-
Descrição: dc.descriptionIBD Outpatient Clinics- Colorectal Surgery Unit Catholic University or Paraná PUCPR-
Descrição: dc.descriptionDepartment of Surgery and Anatomy Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionSurgery Department Universidade Federal de Mato Grosso Do Sul-
Descrição: dc.descriptionFederal University of Alagoas-
Descrição: dc.descriptionSurgery Universidade Do Oeste de Santa Catarina UNOESC-
Descrição: dc.descriptionColorectal Surgery Unit João de Barros Barreto University Hospital Federal University of Pará-
Descrição: dc.descriptionGastroenterologia Fundação Universidade de Pernambuco-
Descrição: dc.descriptionHospital de Clínicas de Passo Fundo-
Descrição: dc.descriptionHospital Universitario Getulio Vargas-
Descrição: dc.descriptionGastroenterology Gastroclinica Cascavel-
Descrição: dc.descriptionDepartment of surgery Faculty of Medicine of São José do Rio Preto, SP-
Descrição: dc.descriptionSETE - Specialized Medical Center, São Paulo-
Descrição: dc.descriptionGastroenterology Hospital de Clínicas da Universidade Federal do Paraná - HCUFPR-
Descrição: dc.descriptionGastroenterology Faculdade de Medicina do ABC-
Descrição: dc.descriptionHospital Universitário Professor Polydoro Ernani de São Thiago da Universidade Federal de Santa Catarina HU-UFSC, Santa Catarina-
Descrição: dc.descriptionGastroenterology Hospital Doutor Dório Silva-
Descrição: dc.descriptionGastroenterology Gastromed-
Descrição: dc.descriptionGastroSaude Clinic, Sao Paulo-
Descrição: dc.descriptionHospital Copa D’Or-
Descrição: dc.descriptionBahia State University UNEB, Bahia-
Descrição: dc.descriptionGastroenterology Division Medical Health Center Federal University of Piaui-
Descrição: dc.descriptionGastroenterology Hospital of the Federal University of Minas Gerais-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Surgery Medical School São Paulo State University Unesp-
Idioma: dc.languageen-
Relação: dc.relationBMC Gastroenterology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdalimumab-
Palavras-chave: dc.subjectAnti-TNF therapy-
Palavras-chave: dc.subjectClinical remission-
Palavras-chave: dc.subjectInfliximab-
Palavras-chave: dc.subjectUlcerative colitis-
Título: dc.titleAnti-TNF therapy for ulcerative colitis in Brazil: a comparative real-world national retrospective multicentric study from the Brazilian study group of IBD (GEDIIB)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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