Thyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and—Gonadal Axes in Zebrafish

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Calgary-
Autor(es): dc.creatorRodrigues, Maira S.-
Autor(es): dc.creatorTovo-Neto, Aldo-
Autor(es): dc.creatorRosa, Ivana F.-
Autor(es): dc.creatorDoretto, Lucas B.-
Autor(es): dc.creatorFallah, Hamideh P.-
Autor(es): dc.creatorHabibi, Hamid R.-
Autor(es): dc.creatorNóbrega, Rafael H.-
Data de aceite: dc.date.accessioned2025-08-21T18:50:50Z-
Data de disponibilização: dc.date.available2025-08-21T18:50:50Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fcell.2022.865948-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241092-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241092-
Descrição: dc.descriptionIn vertebrates, thyroid hormones are critical players in controlling different physiological processes such as development, growth, metabolism among others. There is evidence in mammals that thyroid hormones are also an important component of the hormonal system that controls reproduction, although studies in fish remain poorly investigated. Here, we tested this hypothesis by investigating the effects of methimazole-induced hypothyroidism on the testicular function in adult zebrafish. Treatment of fish with methimazole, in vivo, significantly altered zebrafish spermatogenesis by inhibiting cell differentiation and meiosis, as well as decreasing the relative number of spermatozoa. The observed impairment of spermatogenesis by methimazole was correlated with significant changes in transcript levels for several genes implicated in the control of reproduction. Using an in vitro approach, we also demonstrated that in addition to affecting the components of the brain-pituitary-peripheral axis, T3 (triiodothyronine) also exerts direct action on the testis. These results reinforce the hypothesis that thyroid hormones are an essential element of multifactorial control of reproduction and testicular function in zebrafish and possibly other vertebrate species.-
Descrição: dc.descriptionCanadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNatural Sciences and Engineering Research Council of Canada-
Descrição: dc.descriptionAquaculture Program (CAUNESP) São Paulo State University (UNESP)-
Descrição: dc.descriptionReproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biological Sciences University of Calgary-
Descrição: dc.descriptionAquaculture Program (CAUNESP) São Paulo State University (UNESP)-
Descrição: dc.descriptionReproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Cell and Developmental Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectgerm cell-
Palavras-chave: dc.subjecthypothyroidism-
Palavras-chave: dc.subjectmethimazole-
Palavras-chave: dc.subjectspermatogenesis-
Palavras-chave: dc.subjectthyroid hormones-
Palavras-chave: dc.subjectzebrafish-
Título: dc.titleThyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and—Gonadal Axes in Zebrafish-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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