Melatonin Potentiates Exercise-Induced Increases in Skeletal Muscle PGC-1α and Optimizes Glycogen Replenishment

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFaria, Vinícius Silva-
Autor(es): dc.creatorGobatto, Fúlvia Barros Machado-
Autor(es): dc.creatorScariot, Pedro Paulo Menezes-
Autor(es): dc.creatorZagatto, Alessandro Moura-
Autor(es): dc.creatorBeck, Wladimir Rafael-
Data de aceite: dc.date.accessioned2025-08-21T20:14:06Z-
Data de disponibilização: dc.date.available2025-08-21T20:14:06Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-04-26-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2022.803126-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241071-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241071-
Descrição: dc.descriptionCompelling evidence has demonstrated the effect of melatonin on exhaustive exercise tolerance and its modulatory role in muscle energy substrates at the end of exercise. In line with this, PGC-1α and NRF-1 also seem to act on physical exercise tolerance and metabolic recovery after exercise. However, the literature still lacks reports on these proteins after exercise until exhaustion for animals treated with melatonin. Thus, the aim of the current study was to determine the effects of acute melatonin administration on muscle PGC-1α and NRF-1, and its modulatory role in glycogen and triglyceride contents in rats subjected to exhaustive swimming exercise at an intensity corresponding to the anaerobic lactacidemic threshold (iLAn). In a randomized controlled trial design, thirty-nine Wistar rats were allocated into four groups: control (CG = 10), rats treated with melatonin (MG = 9), rats submitted to exercise (EXG = 10), and rats treated with melatonin and submitted to exercise (MEXG = 10). Forty-eight hours after the graded exercise test, the animals received melatonin (10 mg/kg) or vehicles 30 min prior to time to exhaustion test in the iLAn (tlim). Three hours after tlim the animals were euthanized, followed by muscle collection for specific analyses: soleus muscles for immunofluorescence, gluteus maximus, red and white gastrocnemius for the assessment of glycogen and triglyceride contents, and liver for the measurement of glycogen content. Student t-test for independent samples, two-way ANOVA, and Newman keuls post hoc test were used. MEXG swam 120.3% more than animals treated with vehicle (EXG; p < 0.01). PGC-1α and NRF-1 were higher in MEXG with respect to the CG (p < 0.05); however, only PGC-1α was higher for MEXG when compared to EXG. Melatonin reduced the triglyceride content in gluteus maximus, red and white gastrocnemius (F = 6.66, F = 4.51, and F = 6.02, p < 0.05). The glycogen content in red gastrocnemius was higher in MEXG than in CG (p = 0.01), but not in EXG (p > 0.05). In conclusion, melatonin was found to enhance exercise tolerance, potentiate exercise-mediated increases in PGC-1α, decrease muscle triglyceride content and increase muscle glycogen 3 h after exhaustive exercise, rapidly providing a better cellular metabolic environment for future efforts.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Endocrine Physiology and Physical Exercise Department of Physiological Sciences Federal University of São Carlos—UFSCar-
Descrição: dc.descriptionLaboratory of Applied Sport Physiology School of Applied Sciences University of Campinas—UNICAMP-
Descrição: dc.descriptionLaboratory of Physiology and Sports Performance Department of Physical Education School of Science—Bauru Campus São Paulo State University—UNESP-
Descrição: dc.descriptionLaboratory of Physiology and Sports Performance Department of Physical Education School of Science—Bauru Campus São Paulo State University—UNESP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaerobic exercise-
Palavras-chave: dc.subjectenergy metabolism (MeSH ID: D004734)-
Palavras-chave: dc.subjectergogenic aid-
Palavras-chave: dc.subjectN-acetyl-5-methoxytryptamine-
Palavras-chave: dc.subjectnuclear respiratory factor 1 (NRF-1)-
Palavras-chave: dc.subjectperoxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α)-
Palavras-chave: dc.subjectrecovery-
Palavras-chave: dc.subjectskeletal muscle tissue-
Título: dc.titleMelatonin Potentiates Exercise-Induced Increases in Skeletal Muscle PGC-1α and Optimizes Glycogen Replenishment-
Tipo de arquivo: dc.typelivro digital-
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