Association of CD209 (DC-SIGN) rs735240 SNV with paucibacillary leprosy in the Brazilian population and its functional effects

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstituto Lauro de Souza Lima-
Autor(es): dc.contributorLaboratório de Hanseníase-
Autor(es): dc.contributorDivision of Infection and Immunity-
Autor(es): dc.creatorGermano, Giovanna Valle-
Autor(es): dc.creatorBraga, André Flores-
Autor(es): dc.creatorCamargo, Rodrigo Mendes de-
Autor(es): dc.creatorBallalai, Priscila Betoni-
Autor(es): dc.creatorBezerra, Ohanna Cavalcanti-
Autor(es): dc.creatorManta, Fernanda Saloum de Neves-
Autor(es): dc.creatorBelone, Andréa de Faria Fernandes-
Autor(es): dc.creatorSoares, Cleverson Teixeira-
Autor(es): dc.creatorDas, Pranab Kumar-
Autor(es): dc.creatorMoraes, Milton Ozório-
Autor(es): dc.creatorLatini, Ana Carla Pereira-
Autor(es): dc.creatorSouza, Vânia Niéto Brito de-
Data de aceite: dc.date.accessioned2025-08-21T16:38:29Z-
Data de disponibilização: dc.date.available2025-08-21T16:38:29Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0074-02760220014-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241046-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241046-
Descrição: dc.descriptionBACKGROUND Leprosy, caused by Mycobacterium leprae, is a public health problem in Brazil that affects peripheral nerves, resulting in physical disabilities. During host-pathogen interactions, the immune response determines leprosy outcomes from a localised (paucibacillary) form to a disseminated (multibacillary) form. The recognition of M. leprae involves the DC-SIGN receptor, which is present on the dendritic cells (DCs) and participates in immune activation. OBJECTIVES To evaluate the association of polymorphisms in the promoter region of the gene encoding DC-SIGN (CD209) and the clinical form of leprosy, and to investigate its functional effects. METHODS The study population included 406 leprosy patients from an endemic area in Brazil [310 multibacillary (MB); 96 paucibacillary (PB)]. A functional evaluation based on the effects of the single nucleotide variant (SNV) associated with PB leprosy on the specific immune response was also performed. RESULTS The GA genotype and the presence of the A allele of rs735240 (-939G>A) were associated with PB leprosy [OR: 2.09 (1.18-3.69) and 1.84 (1.07-3.14), respectively]. Carriers of the A allele showed reduced expression of CD209 and TGF-β1 in leprosy lesions in comparison with individuals with GG genotype, in addition to a higher response to the Mitsuda test. CONCLUSION These data suggest that rs735240 influences the immune response against M. leprae and clinical presentation of leprosy.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFaculdade de Medicina de Botucatu Programa de Pós-Graduação em Doenças Tropicais, SP-
Descrição: dc.descriptionSecretaria de Estado da Saúde de São Paulo Instituto Lauro de Souza Lima, SP-
Descrição: dc.descriptionFundação Oswaldo Cruz-Fiocruz Instituto Oswaldo Cruz Laboratório de Hanseníase, RJ-
Descrição: dc.descriptionUniversity of Birmingham College of Medical and Dental Sciences Division of Infection and Immunity Department of Clinical Immunology-
Descrição: dc.descriptionFaculdade de Medicina de Botucatu Programa de Pós-Graduação em Doenças Tropicais, SP-
Descrição: dc.descriptionFAPESP: 2009/01436-1-
Idioma: dc.languageen-
Relação: dc.relationMemorias do Instituto Oswaldo Cruz-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDC-SIGN-
Palavras-chave: dc.subjectleprosy-
Palavras-chave: dc.subjectMycobacterium leprae-
Palavras-chave: dc.subjectsingle nucleotide polymorphism-
Título: dc.titleAssociation of CD209 (DC-SIGN) rs735240 SNV with paucibacillary leprosy in the Brazilian population and its functional effects-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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