Effects of a Biocomplex Formed by Two Scaffold Biomaterials, Hydroxyapatite/Tricalcium Phosphate Ceramic and Fibrin Biopolymer, with Photobiomodulation, on Bone Repair

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Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUnisagrado University Center-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFIASP-
Autor(es): dc.contributorUniversity Center of Adamantina (UniFAI)-
Autor(es): dc.creatorReis, Carlos Henrique Bertoni-
Autor(es): dc.creatorBuchaim, Rogerio Leone-
Autor(es): dc.creatorPomini, Karina Torres-
Autor(es): dc.creatorHamzé, Abdul Latif-
Autor(es): dc.creatorZattiti, Isabella Vasconcelos-
Autor(es): dc.creatorDuarte, Marco Antonio Hungaro-
Autor(es): dc.creatorAlcalde, Murilo Priori-
Autor(es): dc.creatorBarraviera, Benedito-
Autor(es): dc.creatorFerreira Júnior, Rui Seabra-
Autor(es): dc.creatorPontes, Fenelon Martinho Lima-
Autor(es): dc.creatorGrandini, Carlos Roberto-
Autor(es): dc.creatorOrtiz, Adriana de Cássia-
Autor(es): dc.creatorFideles, Simone Ortiz Moura-
Autor(es): dc.creatorEugênio, Renata Maria de Camargo-
Autor(es): dc.creatorRosa Junior, Geraldo Marco-
Autor(es): dc.creatorTeixeira, Daniel de Bortoli-
Autor(es): dc.creatorPereira, Eliana de Souza Bastos Mazuqueli-
Autor(es): dc.creatorPilon, João Paulo Galletti-
Autor(es): dc.creatorMiglino, Maria Angelica-
Autor(es): dc.creatorBuchaim, Daniela Vieira-
Data de aceite: dc.date.accessioned2025-08-21T16:58:39Z-
Data de disponibilização: dc.date.available2025-08-21T16:58:39Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/polym14102075-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241029-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241029-
Descrição: dc.descriptionThere are several treatment methods available for bone repair, although the effectiveness becomes limited in cases of large defects. The objective of this pre-clinical protocol was to evalu-ate the grafting of hydroxyapatite/tricalcium phosphate (BCP) ceramic biomaterial (B; QualyBone BCP®, QualyLive, Amadora, Portugal) together with the heterologous fibrin biopolymer (FB; CE-VAP/UNESP Botucatu, Brazil) and with photobiomodulation (PBM; Laserpulse®, Ibramed, Amparo, Brazil) in the repair process of bone defects. Fifty-six rats were randomly divided into four groups of seven animals each: the biomaterial group (G1/B), the biomaterial plus FB group (G2/BFB); the bioma-terial plus PBM group (G3/B + PBM), and the biomaterial plus FB plus PBM group (G4/BFB + PBM). After anesthesia, a critical defect was performed in the center of the rats’ parietal bones, then filled and treated according to their respective groups. The rats were euthanized at 14 and 42 postopera-tive days. Histomorphologically, at 42 days, the G4/BFB + PBM group showed a more advanced maturation transition, with more organized and mature bone areas forming concentric lamellae. A birefringence analysis of collagen fibers also showed a more advanced degree of maturation for the G4/BFB + PBM group. In the comparison between the groups, in the two experimental periods (14 and 42 days), in relation to the percentage of formation of new bone tissue, a significant difference was found between all groups (G1/B (5.42 ± 1.12; 21.49 ± 4.74), G2/BFB (5.00 ± 0.94; 21.77 ± 2.83), G3/B + PBM (12.65 ± 1.78; 29.29 ± 2.93), and G4/BFB + PBM (12.65 ± 2.32; 31.38 ± 2.89)). It was concluded that the use of PBM with low-level laser therapy (LLLT) positively interfered in the repair process of bone defects previously filled with the biocomplex formed by the heterologous fibrin biopolymer associated with the synthetic ceramic of hydroxyapatite and tricalcium phosphate.-
Descrição: dc.descriptionUNIMAR Beneficent Hospital (HBU) University of Marilia (UNIMAR)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry (FOB/USP) University of São Paulo-
Descrição: dc.descriptionGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of São Paulo (FMVZ/USP)-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR)-
Descrição: dc.descriptionMedical School University of Marilia (UNIMAR)-
Descrição: dc.descriptionDepartment of Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of São Paulo (FOB/USP)-
Descrição: dc.descriptionDepartment of Health Science Unisagrado University Center-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Univ Estadual Paulista UNESP)-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP–Univ Estadual Paulista)-
Descrição: dc.descriptionChemistry Department Faculty of Science São Paulo State University (UNESP–Univ Estadual Paulista)-
Descrição: dc.descriptionLaboratório de Anelasticidade e Biomateriais Physics Department Faculty of Science São Paulo State University (UNESP–Univ Estadual Paulista)-
Descrição: dc.descriptionFaculdade Ibero Americana de São Paulo FIASP-
Descrição: dc.descriptionPostgraduate Program in Animal Health Production and Environment University of Marilia (UNIMAR)-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Univ Estadual Paulista)-
Descrição: dc.descriptionTeaching and Research Coordination of the Medical School University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Univ Estadual Paulista UNESP)-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP–Univ Estadual Paulista)-
Descrição: dc.descriptionChemistry Department Faculty of Science São Paulo State University (UNESP–Univ Estadual Paulista)-
Descrição: dc.descriptionLaboratório de Anelasticidade e Biomateriais Physics Department Faculty of Science São Paulo State University (UNESP–Univ Estadual Paulista)-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Univ Estadual Paulista)-
Idioma: dc.languageen-
Relação: dc.relationPolymers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiomaterials-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectbone repair-
Palavras-chave: dc.subjectfibrin-
Palavras-chave: dc.subjectfibrin tissue adhesive-
Palavras-chave: dc.subjectlow-level laser therapy-
Palavras-chave: dc.subjectphotobiomodulation-
Título: dc.titleEffects of a Biocomplex Formed by Two Scaffold Biomaterials, Hydroxyapatite/Tricalcium Phosphate Ceramic and Fibrin Biopolymer, with Photobiomodulation, on Bone Repair-
Tipo de arquivo: dc.typelivro digital-
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