Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorState University of Paraíba-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Rio Grande do Norte-UFRN-
Autor(es): dc.creatorBarros, Rafaella Moreno-
Autor(es): dc.creatorSilva, Camila Garcia da-
Autor(es): dc.creatorCosta, Kammila Martins Nicolau-
Autor(es): dc.creatorSilva Junior, Arnóbio A. da-
Autor(es): dc.creatorScardueli, Cássio Rocha-
Autor(es): dc.creatorMarcantonio, Rosemary Adriana Chiérici-
Autor(es): dc.creatorChiavacci, Leila Aparecida-
Autor(es): dc.creatorOshiro Junior, João Augusto-
Data de aceite: dc.date.accessioned2025-08-21T18:55:36Z-
Data de disponibilização: dc.date.available2025-08-21T18:55:36Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics14051027-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241019-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241019-
Descrição: dc.descriptionPhysical barrier membranes have been used to release active substances to treat critical bone defects; however, hydrophilic membranes do not present a prolonged release capacity. In this sense, hydrophobic membranes have been tested. Thus, this study aimed to develop hydrophobic membranes based on mixtures of ureasil–polyether-type materials containing incorporated dexamethasone (DMA) for the application in guided bone regeneration. The physicochemical characterization and biological assays were carried out using small-angle X-ray scattering (SAXS), an in vitro DMA release study, atomic force microscopy (AFM), a hemolysis test, and in vivo bone formation. The swelling degree, SAXS, and release results revealed that the u-PPO400/2000 membrane in the proportion of 70:30 showed swelling (4.69% ± 0.22) similar to the proportions 90:10 and 80:20, and lower than the proportion 60:40 (6.38% ± 0.49); however, an equal release percentage after 134 h was observed between the proportions 70:30 and 60:40. All u-PPO materials presented hemocompatibility (hemolysis ≤2.8%). AFM results showed that the treatments with or without DMA did not present significant differences, revealing a flat/smooth surface, with no pores and/or crystalline precipitates. Finally, in vivo results revealed that for both the commercial hydrophilic membrane and u-PPO400/2000 (70:30) after 60 days, the bone formation volume was 21%. In conclusion, hybrid membranes present unique characteristics for treating critical bone defects, considering the delayed and prolonged release results associated with the physical barrier capacity.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPharmaceutical Sciences Postgraduate Center for Biological and Health Sciences State University of Paraíba, Av. Juvêncio Arruda, S/N, Paraíba-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Highway Araraquara-Jaú, Araraquara-
Descrição: dc.descriptionDepartment of Pharmacy Federal University of Rio Grande do Norte-UFRN, Rio Grande do Norte-
Descrição: dc.descriptionFaculty of Dentistry São Paulo State University (UNESP), Araraquara-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Highway Araraquara-Jaú, Araraquara-
Descrição: dc.descriptionFaculty of Dentistry São Paulo State University (UNESP), Araraquara-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 422231/2018-5-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcritical bone defect size-
Palavras-chave: dc.subjecthydrophobic membrane-
Palavras-chave: dc.subjectorganic–inorganic hybrid materials-
Título: dc.titleDexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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