Effects of sodium hexametaphosphate microparticles or nanoparticles on the growth of saliva-derived microcosm biofilms

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Amsterdam and Vrije Universiteit Amsterdam-
Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.creatorSampaio, Caio-
Autor(es): dc.creatorDeng, Dongmei-
Autor(es): dc.creatorExterkate, Rob-
Autor(es): dc.creatorZen, Igor-
Autor(es): dc.creatorHosida, Thayse Yumi-
Autor(es): dc.creatorMonteiro, Douglas Roberto-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Autor(es): dc.creatorPessan, Juliano Pelim-
Data de aceite: dc.date.accessioned2025-08-21T15:27:37Z-
Data de disponibilização: dc.date.available2025-08-21T15:27:37Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-022-04529-3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241003-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241003-
Descrição: dc.descriptionObjectives: This study evaluated the effects of sodium hexametaphosphate microparticles (HMPmicro) or nanoparticles (HMPnano) on the growth of saliva-derived microcosm biofilms Materials and methods: Saliva-derived biofilms were formed on glass coverslips for 24 h. Thereafter, Streptococcus mutans (C180-2) was incorporated or not into the biofilms. From that time point onwards, solutions containing 0.2% HMPmicro or HMPnano, combined or not with 220 ppm F, were constantly present in the culture medium. In addition, 220 ppm F alone (220F) and McBain medium without any compound were also tested as positive and negative controls (CTL), respectively. After 96 h, the biofilms were plated on anaerobic blood agar or sucrose agar bacitracin for total and S. mutans CFU-counting, respectively. Biofilms’ lactic acid production was analysed spectrophotometrically. Data were submitted to ANOVA or Kruskal-Wallis’ tests, followed by Student-Newman-Keuls’ test (p<0.05; n=12). Results: HMPmicro or HMPnano led to significantly lower lactic acid production, and significant reductions in total CFU-counting in microcosm biofilms, supplemented or not with S. mutans, in comparison to both controls, with significant differences between 220F and CTL. No significant differences were observed among the groups treated with HMPmicro or HMPnano (with or without F). The same trend was seen for S. mutans CFU-counting, in biofilms supplemented with S. mutans. Conclusions: HMP significantly reduced total and S. mutans CFU counts, as well as lactic acid production by saliva-derived microcosm biofilms. Clinical relevance: These findings in saliva-derived microcosm biofilms suggest that HMP stands as a promising alternative for the control of cariogenic biofilms.-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry, Rua José Bonifácio, 1193, 16015-050, Araçatuba-
Descrição: dc.descriptionDepartment of Preventive Dentistry Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam-
Descrição: dc.descriptionPostgraduate Program in Health Sciences University of Western São Paulo (UNOESTE), Presidente Prudente-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry, Rua José Bonifácio, 1193, 16015-050, Araçatuba-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiofilms-
Palavras-chave: dc.subjectFluorides-
Palavras-chave: dc.subjectNanotechnology-
Palavras-chave: dc.subjectPhosphates-
Título: dc.titleEffects of sodium hexametaphosphate microparticles or nanoparticles on the growth of saliva-derived microcosm biofilms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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