A Denture Use Model Associated with Candida spp. in Immunocompetent Male and Female Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of California at Los Angeles (UCLA)-
Autor(es): dc.creatorSakima, Vinicius Tatsuyuji-
Autor(es): dc.creatorVega-Chacón, Yuliana-
Autor(es): dc.creatorCerri, Paulo Sergio-
Autor(es): dc.creatorShokeen, Bhumika-
Autor(es): dc.creatorLux, Renate-
Autor(es): dc.creatorMima, Ewerton Garcia de Oliveira-
Data de aceite: dc.date.accessioned2025-08-21T22:35:36Z-
Data de disponibilização: dc.date.available2025-08-21T22:35:36Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof8050466-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240983-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240983-
Descrição: dc.descriptionDenture stomatitis (DS) is a common infection in denture wearers, especially women. This study evaluated the induction of DS using acrylic devices attached to the palate of rats combined with inoculation of Candida spp. Immunocompetent male and female rats received a carbohydraterich diet. Impressions were taken from the rats’ palate to individually fabricate acrylic devices. Mono-and multispecies biofilms of C. albicans, C. glabrata, and C. tropicalis were grown on the devices, which were then cemented on posterior teeth and kept in the rats’ palate for four weeks. Microbial samples from the palate and the device were quantified. Oral microbiome of rats inoculated with C. albicans was analyzed by 16S rRNA gene sequencing. Log10(CFU/mL) were analyzed by mixed or two-way MANOVA (α = 0.05). Candida spp. and acrylic device did not induce palatal inflammation macroscopically nor microscopically. Although there was an increase (p < 0.001) of the total microbiota and female rats demonstrated higher (p = 0.007) recovery of Candida spp. from the palate, the gender differences were not biologically relevant. The microbiome results indicate an increase in inflammatory microbiota and reduction in health-associated micro-organisms. Although Candida spp. and acrylic device did not induce DS in immunocompetent rats, the shift in microbiota may precede manifestation of inflammation.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Applied Microbiology Department of Dental Materials and Prosthodontics School of Dentistry Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Histology and Embryology Department of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Dentistry University of California at Los Angeles (UCLA)-
Descrição: dc.descriptionLaboratory of Applied Microbiology Department of Dental Materials and Prosthodontics School of Dentistry Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Histology and Embryology Department of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2018/02513-9-
Descrição: dc.descriptionCAPES: 88887.468793/2019-00-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectCandida glabrata-
Palavras-chave: dc.subjectCandida tropicalis-
Palavras-chave: dc.subjectdentures-
Palavras-chave: dc.subjectoral candidiasis-
Palavras-chave: dc.subjectrats-
Título: dc.titleA Denture Use Model Associated with Candida spp. in Immunocompetent Male and Female Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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