Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

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Autor(es): dc.contributorForschungszentrum Jülich-
Autor(es): dc.contributorUniversitätsstraße-
Autor(es): dc.contributorHeinrich-Heine-Universität Düsseldorf-
Autor(es): dc.contributorFederal University of Tocantins-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorEberle, Raphael J.-
Autor(es): dc.creatorGering, Ian-
Autor(es): dc.creatorTusche, Markus-
Autor(es): dc.creatorOstermann, Philipp N.-
Autor(es): dc.creatorMüller, Lisa-
Autor(es): dc.creatorAdams, Ortwin-
Autor(es): dc.creatorSchaal, Heiner-
Autor(es): dc.creatorOlivier, Danilo S.-
Autor(es): dc.creatorAmaral, Marcos S.-
Autor(es): dc.creatorArni, Raghuvir K.-
Autor(es): dc.creatorWillbold, Dieter-
Autor(es): dc.creatorCoronado, Mônika A.-
Data de aceite: dc.date.accessioned2025-08-21T23:26:21Z-
Data de disponibilização: dc.date.available2025-08-21T23:26:21Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph15050540-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240958-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240958-
Descrição: dc.descriptionThe C30 endopeptidase (3C-like protease; 3CLpro ) is essential for the life cycle of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) since it plays a pivotal role in viral replication and transcription and, hence, is a promising drug target. Molecules isolated from animals, insects, plants, or microorganisms can serve as a scaffold for the design of novel biopharmaceutical products. Crotamine, a small cationic peptide from the venom of the rattlesnake Crotalus durissus terrificus, has been the focus of many studies since it exhibits activities such as analgesic, in vitro antibacterial, and hemolytic activities. The crotamine derivative L-peptides (L-CDP) that inhibit the 3CL protease in the low µM range were examined since they are susceptible to proteolytic degradation; we explored the utility of their D-enantiomers form. Comparative uptake inhibition analysis showed D-CDP as a promising prototype for a D-peptide-based drug. We also found that the D-peptides can impair SARS-CoV-2 replication in vivo, probably targeting the viral protease 3CLpro .-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Biological Information Processing (IBI−7 Structural Biochemistry) Forschungszentrum Jülich-
Descrição: dc.descriptionInstitut für Physikalische Biologie Heinrich-Heine-Universität Düsseldorf Universitätsstraße-
Descrição: dc.descriptionInstitute of Virology Medical Faculty University Hospital Düsseldorf Heinrich-Heine-Universität Düsseldorf-
Descrição: dc.descriptionIntegrated Sciences Center Federal University of Tocantins, Campus Cimba, TO-
Descrição: dc.descriptionInstitute of Physics Federal University of Mato Grosso do Sul, MS-
Descrição: dc.descriptionMultiuser Center for Biomolecular Innovation Department of Physics IBILCE Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionJuStruct: Jülich Centre for Structural Biology Forschungszentrum Jülich-
Descrição: dc.descriptionMultiuser Center for Biomolecular Innovation Department of Physics IBILCE Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2016/12904-0-
Descrição: dc.descriptionFAPESP: 2018/07572-3-
Descrição: dc.descriptionFAPESP: 2018/12659-0-
Descrição: dc.descriptionFAPESP: 2019/05614-3-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject3CLpro-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectcrotamine derivative peptides-
Palavras-chave: dc.subjectD-peptides-
Palavras-chave: dc.subjectinhibitor-
Palavras-chave: dc.subjectmain protease-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleDesign of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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