Diagnosis and Management of Preeclampsia: Suggested Guidance on the Use of Biomarkers

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorPontifícia Universidade Católica de São Paulo-
Autor(es): dc.contributorHospital Moinhos de Vento-HMV-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCosta, Maria Laura-
Autor(es): dc.creatorCavalli, Ricardo de Carvalho-
Autor(es): dc.creatorKorkes, Henri Augusto-
Autor(es): dc.creatorCunha Filho, Edson Vieira Da-
Autor(es): dc.creatorPeraçoli, José Carlos-
Data de aceite: dc.date.accessioned2025-08-21T22:11:30Z-
Data de disponibilização: dc.date.available2025-08-21T22:11:30Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1055/s-0042-1744286-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240954-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240954-
Descrição: dc.descriptionObjective It is a challenge to consider preeclampsia (PE) diagnosis and management in low and middle-income settings, where it represents a major public health concern. The placenta is the underlying cause of disease, and the plasma concentrations of proangiogenic and antiangiogenic factors released by the placenta can reflect the risks of disease progression. Antiangiogenic proteins, such as soluble fms-like tyrosine kinase 1 (sFlt-1), and proangiogenic, like placental growth factors (PlGF), are directly and inversely correlated with the disease onset, respectively. Methods Narrative review on the use of biomarkers (sFlt-1 to PlGF ratio) with a suggested guidance protocol. Results Key considerations on the use of biomarkers: the sFlt-1/PlGF ratio is mainly relevant to rule out PE between 20 and 36 6/7 weeks in cases of suspected PE; however, it should not replace the routine exams for the diagnosis of PE. The sFlt-1/PlGF ratio should not be performed after confirmed PE diagnosis (only in research settings). In women with suspected PE, sFlt-1/PlGF ratio < 38 can rule out the diagnosis of PE for 1 week (VPN = 99.3) and up to 4 weeks (VPN= 94.3); sFlt-1/PlGF ratio > 38 does not confirm the diagnosis of PE; however, it can assist clinical management. In cases of severe hypertension and/or symptoms (imminent eclampsia), hospitalization is imperative, regardless of the result of the sFlt-1/PlGF ratio. Conclusion The use of biomarkers can help support clinical decisions on the management of suspected PE cases, especially to rule out PE diagnosis, thus avoiding unnecessary interventions, especially hospitalizations and elective prematurity.-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Universidade Estadual de Campinas, SP-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, SP-
Descrição: dc.descriptionDepartment of Human Reproduction and Childhood Pontifícia Universidade Católica de São Paulo, SP-
Descrição: dc.descriptionObstetrics and Gynecology Department Hospital Moinhos de Vento-HMV, RS-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho, SP-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho, SP-
Idioma: dc.languageen-
Relação: dc.relationRevista Brasileira de Ginecologia e Obstetricia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjecthypertension-
Palavras-chave: dc.subjectplacental growth factor-
Palavras-chave: dc.subjectpreeclampsia-
Palavras-chave: dc.subjectpreterm preeclampsia-
Palavras-chave: dc.subjectsoluble fms-like tyrosine kinase 1-
Título: dc.titleDiagnosis and Management of Preeclampsia: Suggested Guidance on the Use of Biomarkers-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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