Genomic integration to identify molecular biomarkers associated with indicator traits of gastrointestinal nematode resistance in sheep

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorInstituto Nacional de Investigación Agropecuária (INIA)-
Autor(es): dc.contributorUniversity of Guelph-
Autor(es): dc.creatorBerton, Mariana Piatto-
Autor(es): dc.creatorSilva, Rosiane Pereira da-
Autor(es): dc.creatorBanchero, Georgget-
Autor(es): dc.creatorMourão, Gerson Barreto-
Autor(es): dc.creatorFerraz, Jose Bento Sterman-
Autor(es): dc.creatorSchenkel, Flavio Schramm-
Autor(es): dc.creatorBaldi, Fernando-
Data de aceite: dc.date.accessioned2025-08-21T23:18:14Z-
Data de disponibilização: dc.date.available2025-08-21T23:18:14Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jbg.12682-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240953-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240953-
Descrição: dc.descriptionThis study aimed to integrate GWAS and structural variants to propose possible molecular biomarkers related to gastrointestinal nematode resistance traits in Santa Inês sheep. The phenotypic records FAMACHA, haematocrit, white blood cell count, red blood cell count, haemoglobin, platelets and egg counts per gram of faeces were collected from 700 naturally infected animals, belonging to four Brazilian flocks. A total of 576 animals were genotyped using the Ovine SNP12k BeadChip and were imputed using a reference population with Ovine SNP50 BeadChip. The GWAS approaches were based on SNPs, haplotypes, CNVs and ROH. The overlapping between the significant genomic regions detected from all approaches was investigated, and the results were integrated using a network analysis. Genes related to the immune system were found, such as ABCB1, IL6, WNT5A and IRF5. Genomic regions containing candidate genes and metabolic pathways involved in immune responses, inflammatory processes and immune cells affecting parasite resistance traits were identified. The genomic regions, biological processes and candidate genes uncovered could lead to biomarkers for selecting more resilient sheep and improving herd welfare and productivity. The results obtained are the start point to identify molecular biomarkers related to indicator traits of gastrointestinal nematode resistance in Santa Inês sheep.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartamento de Zootecnia Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista-
Descrição: dc.descriptionFaculdade de Zootecnia e Engenharia de Alimentos Universidade de São Paulo-
Descrição: dc.descriptionInstituto Nacional de Investigación Agropecuária (INIA)-
Descrição: dc.descriptionDepartamento de Zootecnia Escola Superior de Agricultura “Luiz de Queiroz” Universidade de São Paulo/ESALQ-
Descrição: dc.descriptionCentre for Genetic Improvement of Livestock University of Guelph-
Descrição: dc.descriptionDepartamento de Zootecnia Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista-
Descrição: dc.descriptionFAPESP: 2014/07566--
Descrição: dc.descriptionFAPESP: 2018/25247-2-
Formato: dc.format502-516-
Idioma: dc.languageen-
Relação: dc.relationJournal of Animal Breeding and Genetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcopy number variant-
Palavras-chave: dc.subjectGWAS-
Palavras-chave: dc.subjecthaplotype-
Palavras-chave: dc.subjectintegration analyses-
Palavras-chave: dc.subjectrun of homozygosity-
Palavras-chave: dc.subjectsystem biology-
Título: dc.titleGenomic integration to identify molecular biomarkers associated with indicator traits of gastrointestinal nematode resistance in sheep-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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