Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversity Center of Adamantina (UniFAI)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaculties of Dracena (FUNDEC Unifadra)-
Autor(es): dc.contributorSão Leopoldo Mandic (SLMANDIC)-
Autor(es): dc.creatorOrtiz, Adriana de Cássia-
Autor(es): dc.creatorFideles, Simone Ortiz Moura-
Autor(es): dc.creatorReis, Carlos Henrique Bertoni-
Autor(es): dc.creatorBellini, Márcia Zilioli-
Autor(es): dc.creatorPereira, Eliana de Souza Bastos Mazuqueli-
Autor(es): dc.creatorPilon, João Paulo Galletti-
Autor(es): dc.creatorMarchi, Miguel Ângelo de-
Autor(es): dc.creatorDetregiachi, Cláudia Rucco Penteado-
Autor(es): dc.creatorFlato, Uri Adrian Prync-
Autor(es): dc.creatorTrazzi, Beatriz Flavia de Moraes-
Autor(es): dc.creatorPagani, Bruna Trazzi-
Autor(es): dc.creatorPonce, José Burgos-
Autor(es): dc.creatorGardizani, Taiane Priscila-
Autor(es): dc.creatorVeronez, Fulvia de Souza-
Autor(es): dc.creatorBuchaim, Daniela Vieira-
Autor(es): dc.creatorBuchaim, Rogerio Leone-
Data de aceite: dc.date.accessioned2025-08-21T20:00:41Z-
Data de disponibilização: dc.date.available2025-08-21T20:00:41Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biom12050626-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240880-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240880-
Descrição: dc.descriptionFlavonoids are natural phytochemicals that have therapeutic effects and act in the prevention of several pathologies. These phytochemicals can be found in seeds, grains, tea, coffee, wine, chocolate, cocoa, vegetables and, mainly, in citrus fruits. Neohesperidin, hesperidin and hesperetin are citrus flavonoids from the flavanones subclass that have anti-inflammatory and antioxidant potential. Neohesperidin, in the form of neohesperidin dihydrochalcone (NHDC), also has dietary properties as a sweetener. In general, these flavanones have been investigated as a strategy to control bone diseases, such as osteoporosis and osteoarthritis. In this literature review, we compiled studies that investigated the effects of neohesperidin, hesperidin and its aglycone, hesperetin, on bone health. In vitro studies showed that these flavanones exerted an antiosteoclastic and anti-inflammatory effects, inhibiting the expression of osteoclastic markers and reducing the levels of reactive oxygen species, proinflammatory cytokines and matrix metalloproteinase levels. Similarly, such studies favored the osteogenic potential of preosteoblastic cells and induced the overexpression of osteogenic markers. In vivo, these flavanones favored the regeneration of bone defects and min-imized inflammation in arthritis-and periodontitis-induced models. Additionally, they exerted a significant anticatabolic effect in ovariectomy models, reducing trabecular bone loss and increasing bone mineral density. Although research should advance to the clinical field, these flavanones may have therapeutic potential for controlling the progression of metabolic, autoimmune or inflammatory bone diseases.-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry (FOB/USP) University of São Paulo-
Descrição: dc.descriptionUNIMAR Beneficent Hospital (HBU) Faculty of Medicine University of Marilia (UNIMAR)-
Descrição: dc.descriptionPro-Rectory of Research and Graduate Studies University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR)-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Univ Estadual Paulista)-
Descrição: dc.descriptionCoordination of the Medical School University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionCoordination of the Dentistry School University of Marilia (UNIMAR)-
Descrição: dc.descriptionDentistry School University of Marilia (UNIMAR)-
Descrição: dc.descriptionMedicine Department University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionMedicine Department Faculties of Dracena (FUNDEC Unifadra)-
Descrição: dc.descriptionFaculty of Medicine São Leopoldo Mandic (SLMANDIC)-
Descrição: dc.descriptionPro-Rectory of Teaching University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionTeaching and Research Coordination of the Medical School University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of São Paulo (FMVZ/USP)-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Univ Estadual Paulista)-
Idioma: dc.languageen-
Relação: dc.relationBiomolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbone-
Palavras-chave: dc.subjectbone health-
Palavras-chave: dc.subjectbone repair-
Palavras-chave: dc.subjectflavonoids-
Palavras-chave: dc.subjecthesperetin-
Palavras-chave: dc.subjecthesperidin-
Palavras-chave: dc.subjectneohesperidin-
Título: dc.titleTherapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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