Phytochemical and antidiabetic analysis of Curatella americana L. aqueous extract on the rat pregnancy

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Autor(es): dc.contributorFederal University of Mato Grosso-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCruz, Larissa Lopes-
Autor(es): dc.creatorSilva, Bruno Stefano Ferreira-
Autor(es): dc.creatorAraujo, Gabriel Gomes-
Autor(es): dc.creatorLeal-Silva, Thaís-
Autor(es): dc.creatorPaula, Verônyca Gonçalves-
Autor(es): dc.creatorSouza, Maysa Rocha-
Autor(es): dc.creatorSoares, Thaigra Souza-
Autor(es): dc.creatorMoraes-Souza, Rafaianne Queiroz-
Autor(es): dc.creatorMonteiro, Gean Charles-
Autor(es): dc.creatorLima, Giuseppina Pace Pereira-
Autor(es): dc.creatorDamasceno, Débora Cristina-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Data de aceite: dc.date.accessioned2025-08-21T21:01:51Z-
Data de disponibilização: dc.date.available2025-08-21T21:01:51Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jep.2022.115287-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240860-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240860-
Descrição: dc.descriptionEthnopharmacological relevance: Curatella americana L. is employed in popular medicine for treating diabetes. However, the understanding around its outcomes during pregnancy is unclear. Aim of the study: To evaluate the phytochemical and hypoglycemic analysis of the C. americana extract and its maternal-fetal effect on diabetic rats. Materials and method: Diabetes was chemically induced 24 h after birth in Wistar female newborn rats. At adulthood, after diabetes status confirmation, the rats were mated and randomized into four experimental groups: Nondiabetic (Control): given water; Treated: given C. americana extract; Diabetic, and Treated Diabetic rats. The aqueous extract of C. americana leaves (300 mg/kg) was administered daily through oral route during pregnancy. Maternal toxicity and biochemical profile, reproductive outcomes, fetal development, and phenolic composition and biogenic amines in aqueous extract were analyzed. Results and conclusion: Phytochemical analysis revealed that the main phenolic components are 3-hydroxytyrosol, kaempferol, and quercetin, while tryptophan and putrescine derivatives were identified as the dominant amines. C. americana extract treatment improved the lipid profile, although no effect on hyperglycemic control in diabetic rats was observed. Maternal diabetes or C. americana extract caused embryo losses confirmed by the lower number of pre-embryos in early pregnancy and higher percentage of abnormal morphologically pre-embryos. C. americana extract previously caused premature pre-embryo fixation before implantation window in nondiabetic and diabetic mothers and intrauterine growth restriction in the fetuses of treated nondiabetic dams, complicating the embryo fetal development. These findings reinforce the caution of indiscriminate use of medicinal plants, especially during pregnancy.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso, Mato Grosso State-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Bioscience São Paulo State University, São Paulo-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Bioscience São Paulo State University, São Paulo-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationJournal of Ethnopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectImplantation-
Palavras-chave: dc.subjectMedicinal plants-
Palavras-chave: dc.subjectPolyamides-
Palavras-chave: dc.subjectPolyphenols-
Palavras-chave: dc.subjectPregnancy-
Título: dc.titlePhytochemical and antidiabetic analysis of Curatella americana L. aqueous extract on the rat pregnancy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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