Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Autor(es): dc.contributorHospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)-
Autor(es): dc.creatorAbichabki, Nathália-
Autor(es): dc.creatorZacharias, Luísa V.-
Autor(es): dc.creatorMoreira, Natália C.-
Autor(es): dc.creatorBellissimo-Rodrigues, Fernando-
Autor(es): dc.creatorMoreira, Fernanda L.-
Autor(es): dc.creatorBenzi, Jhohann R. L.-
Autor(es): dc.creatorOgasawara, Tânia M. C.-
Autor(es): dc.creatorFerreira, Joseane C.-
Autor(es): dc.creatorRibeiro, Camila M.-
Autor(es): dc.creatorPavan, Fernando R.-
Autor(es): dc.creatorPereira, Leonardo R. L.-
Autor(es): dc.creatorBrancini, Guilherme T. P.-
Autor(es): dc.creatorBraga, Gilberto Ú. L.-
Autor(es): dc.creatorZuardi, Antonio W.-
Autor(es): dc.creatorHallak, Jaime E. C.-
Autor(es): dc.creatorCrippa, José A. S.-
Autor(es): dc.creatorLanchote, Vera L.-
Autor(es): dc.creatorCantón, Rafael-
Autor(es): dc.creatorDarini, Ana Lúcia C.-
Autor(es): dc.creatorAndrade, Leonardo N.-
Data de aceite: dc.date.accessioned2025-08-21T15:59:26Z-
Data de disponibilização: dc.date.available2025-08-21T15:59:26Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-022-10393-8-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240855-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240855-
Descrição: dc.descriptionThis study aimed to assess the ultrapure cannabidiol (CBD) antibacterial activity and to investigate the antibacterial activity of the combination CBD + polymyxin B (PB) against Gram-negative (GN) bacteria, including PB-resistant Gram-negative bacilli (GNB). We used the standard broth microdilution method, checkerboard assay, and time-kill assay. CBD exhibited antibacterial activity against Gram-positive bacteria, lipooligosaccharide (LOS)-expressing GN diplococcus (GND) (Neisseria gonorrhoeae, Neisseria meningitidis, Moraxella catarrhalis), and Mycobacterium tuberculosis, but not against GNB. For most of the GNB studied, our results showed that low concentrations of PB (≤ 2 µg/mL) allow CBD (≤ 4 µg/mL) to exert antibacterial activity against GNB (e.g., Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii), including PB-resistant GNB. CBD + PB also showed additive and/or synergistic effect against LOS-expressing GND. Time-kill assays results showed that the combination CBD + PB leads to a greater reduction in the number of colony forming units per milliliter compared to CBD and PB alone, at the same concentration used in combination, and the combination CBD + PB was synergistic for all four PB-resistant K. pneumoniae isolates evaluated. Our results show that CBD has translational potential and should be further explored as a repurposed antibacterial agent in clinical trials. The antibacterial efficacy of the combination CBD + PB against multidrug-resistant and extensively drug-resistant GNB, especially PB-resistant K. pneumoniae, is particularly promising.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Clinical Analyses Toxicology and Food Science (DACTB) School of Pharmaceutical Sciences of Ribeirao Preto (FCFRP) University of São Paulo (USP), Av. do Café, s/nº, Campus Universitário, SP-
Descrição: dc.descriptionDepartment of Social Medicine Ribeirão Preto Medical School (FMRP) University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences (FCF) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences (DCF) School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP) University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Neurosciences and Behavioral Sciences Ribeirão Preto Medical School (FMRP) University of São Paulo (USP), SP-
Descrição: dc.descriptionNational Institute of Science and Technology for Translational Medicine (INCT-TM) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), DF-
Descrição: dc.descriptionHospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences (FCF) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: 130766/2021-6-
Descrição: dc.descriptionCAPES: 8887.369851/2019-00-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titlePotential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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