Potential of curcumin-loaded cubosomes for topical treatment of cervical cancer

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorETH Zurich-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstitute for Maternal and Child Health-IRCCS ‘‘Burlo Garofolo’’-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Cagliari-
Autor(es): dc.contributorConsorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase-
Autor(es): dc.contributorPaul Scherrer Institure PSI-
Autor(es): dc.creatorVictorelli, Francesca Damiani-
Autor(es): dc.creatorManni, Livia Salvati-
Autor(es): dc.creatorBiffi, Stefania-
Autor(es): dc.creatorBortot, Barbara-
Autor(es): dc.creatorBuzzá, Hilde Harb-
Autor(es): dc.creatorLutz-Bueno, Viviane-
Autor(es): dc.creatorHandschin, Stephan-
Autor(es): dc.creatorCalixto, Giovana-
Autor(es): dc.creatorMurgia, Sergio-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorMezzenga, Raffaele-
Data de aceite: dc.date.accessioned2025-08-21T17:24:31Z-
Data de disponibilização: dc.date.available2025-08-21T17:24:31Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jcis.2022.04.031-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240852-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240852-
Descrição: dc.descriptionCervical cancer is one of the most common cancers affecting women worldwide. There are an estimated 570.000 new cases of cervical cancer each year and conventional treatments can cause severe side effects. In this work, we developed a platform for vaginal administration of lipophilic drugs for cervical cancer treatment. We formulated mucoadhesive cubosomes for the delivery of curcumin, a lipophilic drug for cervical cancer treatment, to increase its bioavailability and local absorption. This study tests the use of cubosomes for vaginal drug administration and assesses their potential efficiency using the CAM (chick embryo chorioallantoic membrane) model. SAXS (small-angle X-ray scattering), cryo-TEM (cryo-transmission electron microscopy), and dynamic light scattering (DLS) were employed to characterise the system. With ex vivo permeation and retention studies, we find that the curcumin released from our system is retained in the vaginal mucosa. In vitro cytotoxicity assay and cellular uptake showed an increased cytotoxic effect of curcumin against HeLa cell line when incorporated into the cubosomes. The curcumin-loaded cubosomes also demonstrated an antiangiogenic effect evaluated in vivo by the CAM model.-
Descrição: dc.descriptionDepartment of Health Sciences and Technology ETH Zurich-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University, Sao Paulo-
Descrição: dc.descriptionInstitute for Maternal and Child Health-IRCCS ‘‘Burlo Garofolo’’-
Descrição: dc.descriptionSão Carlos Institute of Physics University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionInstitute of Physics Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionUNICAMP University of Campinas Piracicaba Dental School Department of Biosciences, São Paulo-
Descrição: dc.descriptionDepartment of Life and Environmental Sciences University of Cagliari-
Descrição: dc.descriptionCSGI Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, via della Lastruccia 3-
Descrição: dc.descriptionDepartment of Materials ETH Zurich-
Descrição: dc.descriptionPaul Scherrer Institure PSI-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University, Sao Paulo-
Formato: dc.format419-430-
Idioma: dc.languageen-
Relação: dc.relationJournal of Colloid and Interface Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCervical cancer-
Palavras-chave: dc.subjectChorioallantoic membrane model-
Palavras-chave: dc.subjectCubosomes-
Palavras-chave: dc.subjectDOTAP-
Palavras-chave: dc.subjectMucoadhesion-
Palavras-chave: dc.subjectVaginal administration-
Título: dc.titlePotential of curcumin-loaded cubosomes for topical treatment of cervical cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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