Genital Mycoplasmas and Biomarkers of Inflammation and Their Association With Spontaneous Preterm Birth and Preterm Prelabor Rupture of Membranes: A Systematic Review and Meta-Analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorThe University of Texas Medical Branch at Galveston-
Autor(es): dc.contributorUniversity of the Philippines Manila-
Autor(es): dc.contributorUniversidade Federal da Fronteira Sul-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorUniversity of Southern Denmark-
Autor(es): dc.contributorUniversity College London-
Autor(es): dc.contributorUniversity of Texas Medical Branch-
Autor(es): dc.creatorNoda-Nicolau, Nathalia M.-
Autor(es): dc.creatorTantengco, Ourlad Alzeus G.-
Autor(es): dc.creatorPolettini, Jossimara-
Autor(es): dc.creatorSilva, Mariana C.-
Autor(es): dc.creatorBento, Giovana F. C.-
Autor(es): dc.creatorCursino, Geovanna C.-
Autor(es): dc.creatorMarconi, Camila-
Autor(es): dc.creatorLamont, Ronald F.-
Autor(es): dc.creatorTaylor, Brandie D.-
Autor(es): dc.creatorSilva, Márcia G.-
Autor(es): dc.creatorJupiter, Daniel-
Autor(es): dc.creatorMenon, Ramkumar-
Data de aceite: dc.date.accessioned2025-08-21T15:14:05Z-
Data de disponibilização: dc.date.available2025-08-21T15:14:05Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-03-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmicb.2022.859732-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240851-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240851-
Descrição: dc.descriptionGenital mycoplasmas (GM), such as Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma parvum, and Ureaplasma urealyticum are commonly associated with spontaneous preterm labor (SPTL), spontaneous preterm birth (PTB), and preterm prelabor rupture of membranes (PPROM). This study determined the association between GM and such adverse pregnancy outcomes. We searched for studies published 1980–2019 in MEDLINE, EMBASE, and Web of Science. Studies were eligible when GM was detected during pregnancy. We included 93 and 51 studies in determining the prevalence and the inflammatory biomarkers associated with GM, respectively, using the “metafor” package within R. The protocol was registered with PROSPERO (registration no. CRD42016047297). Women with the studied adverse pregnancy outcomes had significantly higher odds of presence with GM compared to women who delivered at term. For PTB, the odds ratios were: M. hominis (OR: 2.25; CI: 1.35–3.75; I2: 44%), M. genitalium (OR: 2.04; CIL 1.18–3.53; I2: 20%), U. parvum (OR: 1.75; CI: 1.47–2.07; I2: 0%), U. urealyticum (OR: 1.50; CI: 1.08–2.07; I2: 58%). SPTL had significantly higher odds with M. hominis (OR: 1.96; CI: 1.19–3.23; I2: 1%) or U. urealyticum (OR: 2.37; CI: 1.20–4.70; I2: 76%) compared to women without SPTL. Women with PPROM had significantly higher odds with M. hominis (OR: 2.09; CI: 1.42–3.08; I2: 0%) than women without PPROM. However, our subgroup analysis based on the diagnostic test and the sample used for detecting GM showed a higher prevalence of GM in maternal samples than in fetal samples. GM presence of the cervix and vagina was associated with lower odds of PTB and preterm labor (PTL). In contrast, GM presence in the AF, fetal membrane, and placenta was associated with increased odds of PTB and PTL. However, genital mycoplasmas may not elicit the massive inflammation required to trigger PTB. In conclusion, GM presence in the fetal tissues was associated with significantly increased odds of PTB and PTL.-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Universidade Estadual Paulista-
Descrição: dc.descriptionDivision of Basic and Translational Research Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston-
Descrição: dc.descriptionDepartment of Biochemistry and Molecular Biology College of Medicine University of the Philippines Manila-
Descrição: dc.descriptionGraduate Program in Biomedical Sciences Universidade Federal da Fronteira Sul-
Descrição: dc.descriptionDepartment of Basic Pathology Universidade Federal do Paraná, Setor de Ciências Biológicas-
Descrição: dc.descriptionResearch Unit of Gynaecology and Obstetrics Department of Gynecology and Obstetrics Institute of Clinical Research University of Southern Denmark-
Descrição: dc.descriptionDivision of Surgery Northwick Park Institute for Medical Research University College London-
Descrição: dc.descriptionDepartment of Preventive Medicine and Community Health University of Texas Medical Branch-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Universidade Estadual Paulista-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectinflammatory cytokines-
Palavras-chave: dc.subjectMycoplasma species-
Palavras-chave: dc.subjectpregnancy-
Palavras-chave: dc.subjectpregnancy adverse outcomes-
Palavras-chave: dc.subjectpreterm birth-
Palavras-chave: dc.subjectUreaplasma species-
Título: dc.titleGenital Mycoplasmas and Biomarkers of Inflammation and Their Association With Spontaneous Preterm Birth and Preterm Prelabor Rupture of Membranes: A Systematic Review and Meta-Analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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