How HLA diversity is apportioned: Influence of selection and relevance to transplantation

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Washington-
Autor(es): dc.contributorUniversity of Lausanne-
Autor(es): dc.creatorMaróstica, André Silva-
Autor(es): dc.creatorNunes, Kelly-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorSilva, Nayane S. B.-
Autor(es): dc.creatorWeir, Bruce S.-
Autor(es): dc.creatorGoudet, Jérôme-
Autor(es): dc.creatorMeyer, Diogo-
Data de aceite: dc.date.accessioned2025-08-21T16:23:07Z-
Data de disponibilização: dc.date.available2025-08-21T16:23:07Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1098/rstb.2020.0420-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240844-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240844-
Descrição: dc.descriptionIn his 1972 paper The apportionment of human diversity', Lewontin showed that, when averaged over loci, genetic diversity is predominantly attributable to differences among individuals within populations. However, selection can alter the apportionment of diversity of specific genes or genomic regions. We examine genetic diversity at the human leucocyte antigen (HLA) loci, located within the major histocompatibility complex (MHC) region. HLA genes code for proteins that are critical to adaptive immunity and are well-documented targets of balancing selection. The single-nucleotide polymorphisms (SNPs) within HLA genes show strong signatures of balancing selection on large timescales and are broadly shared among populations, displaying low F ST values. However, when we analyse haplotypes defined by these SNPs (which define HLA alleles'), we find marked differences in frequencies between geographic regions. These differences are not reflected in the F ST values because of the extreme polymorphism at HLA loci, illustrating challenges in interpreting F ST. Differences in the frequency of HLA alleles among geographic regions are relevant to bone-marrow transplantation, which requires genetic identity at HLA loci between patient and donor. We discuss the case of Brazil's bone marrow registry, where a deficit of enrolled volunteers with African ancestry reduces the chance of finding donors for individuals with an MHC region of African ancestry. This article is part of the theme issue Celebrating 50 years since Lewontin's apportionment of human diversity'.-
Descrição: dc.descriptionDepartamento de Genética e Biologia Evolutiva Universidade de São Paulo, SP-
Descrição: dc.descriptionDepartamento de Patologia Universidade Estadual Paulista - Unesp Faculdade de Medicina de Botucatu, SP-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory Experimental Research Unit School of Medicine São Paulo State University - Unesp, SP-
Descrição: dc.descriptionDepartment of Biostatistics University of Washington-
Descrição: dc.descriptionDepartment of Ecology and Evolution University of Lausanne-
Descrição: dc.descriptionSwiss Institute of Bioinformatics University of Lausanne-
Descrição: dc.descriptionDepartamento de Patologia Universidade Estadual Paulista - Unesp Faculdade de Medicina de Botucatu, SP-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory Experimental Research Unit School of Medicine São Paulo State University - Unesp, SP-
Idioma: dc.languageen-
Relação: dc.relationPhilosophical Transactions of the Royal Society B: Biological Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHLA genes-
Palavras-chave: dc.subjectMHC-
Palavras-chave: dc.subjectPopulation structure-
Palavras-chave: dc.subjectpopulation-specific F ST-
Palavras-chave: dc.subjecttransplantation-
Título: dc.titleHow HLA diversity is apportioned: Influence of selection and relevance to transplantation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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