Genetic deletion of IL-6 increases CK-MB, a classic cardiac damage marker, and decreases UPRmt genes after exhaustive exercise

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRovina, Rafael L.-
Autor(es): dc.creatorPinto, Ana P.-
Autor(es): dc.creatorMuñoz, Vitor R.-
Autor(es): dc.creatorRocha, Alisson L. da-
Autor(es): dc.creatorRebelo, Macario A.-
Autor(es): dc.creatorTeixeira, Giovana R.-
Autor(es): dc.creatorTavares, Maria Eduarda A.-
Autor(es): dc.creatorPauli, José R.-
Autor(es): dc.creatorMoura, Leandro P. de-
Autor(es): dc.creatorCintra, Dennys E.-
Autor(es): dc.creatorRopelle, Eduardo R.-
Autor(es): dc.creatorSilva, Adelino S. R. da-
Data de aceite: dc.date.accessioned2025-08-21T23:16:35Z-
Data de disponibilização: dc.date.available2025-08-21T23:16:35Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/cbf.3701-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240836-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240836-
Descrição: dc.descriptionThe intensity, duration, type of contraction, and muscle damage influence interleukin-6 (IL-6) response to acute exercise. However, in response to an exhaustive exercise session, the upregulation of IL-6 in the serum and heart is associated with an inflammatory condition and can inhibit autophagy. This study aimed to investigate the role of IL-6 in autophagy pathway responses and mitochondrial function in the heart of mice submitted to acute exhaustive physical exercise. The mice were allocated into three groups, five animals per group, for the wild type (WT) and the IL-6 knockout (IL-6 KO): Basal (sedentary; Basal), 1 h (after 1 h of the acute exercise; 1 h), and 3 h (after 3 h of the acute exercise; 3 h). After the specific time for each group, the blood was collected, each mouse heart was removed, and the left ventricle (LV) was isolated. In summary, under basal conditions, without the influence of the acute exercise, the IL-6 KO group showed lower number of nuclei in the cardiac tissue, but higher collagen deposition; lower messenger RNA (mRNA) levels of Prkaa1 and Mtco1, but higher mRNA levels of Ulk1; and higher protein levels of the ratio p-AMPK/AMPK in the heart when compared to WT at the same time point. After the acute exercise (1 and 3 h), the IL-6 KO group had lower mRNA levels of Tfam, Mtnd1, Mtco1, and Nampt in the heart when compared to WT after exercise; higher serum levels of creatine kinase (CK), CK-MB, and lactate dehydrogenase for the IL-6 group when compared to the WT group after the exercise. Specifically, the heat-shock protein 60 protein levels in the heart increased 3 h after exhaustive exercise in the WT group, but not in the IL-6 KO group. The study emphasizes that IL-6 may offer cardioprotective effects, including mitochondrial adaptations in response to acute exhaustive exercise.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Faculty of Medicinal Sciences, State University of Campinas (UNICAMP) University of Campinas, São Paulo-
Descrição: dc.descriptionMulticentric Program of Postgraduate in Physiological Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP), São Paulo-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise (LaBMEx) School of Applied Sciences University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionMulticentric Program of Postgraduate in Physiological Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP), São Paulo-
Formato: dc.format369-378-
Idioma: dc.languageen-
Relação: dc.relationCell Biochemistry and Function-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectautophagy-
Palavras-chave: dc.subjectcardiac tissue-
Palavras-chave: dc.subjectexercise-
Palavras-chave: dc.subjectinterleukin-6-
Palavras-chave: dc.subjectmitochondria-
Título: dc.titleGenetic deletion of IL-6 increases CK-MB, a classic cardiac damage marker, and decreases UPRmt genes after exhaustive exercise-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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