Encephalopathy responsive to thiamine in severe COVID-19 patients

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUnimed Hospital of Araçatuba-
Autor(es): dc.contributorUniversity of the Region of Joinville (UNIVILLE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOliveira, Marcus Vinicius Branco de-
Autor(es): dc.creatorIrikura, Sergio-
Autor(es): dc.creatorLourenço, Fabiani Honorato de Barros-
Autor(es): dc.creatorShinsato, Monica-
Autor(es): dc.creatorIrikura, Tereza Cristina Duarte Batista-
Autor(es): dc.creatorIrikura, Rodrigo Batista-
Autor(es): dc.creatorAlbuquerque, Tales Vieira Cavalvanti-
Autor(es): dc.creatorShinsato, Vilma Neri-
Autor(es): dc.creatorOrsatti, Vinicius Nakad-
Autor(es): dc.creatorFontanelli, Antônio Mendes-
Autor(es): dc.creatorSamegima, Danyelle Amélia Grecco-
Autor(es): dc.creatorGonçalves, Marcus Vinícius Magno-
Autor(es): dc.creatorBernabé, Daniel Galera-
Data de aceite: dc.date.accessioned2025-08-21T20:46:20Z-
Data de disponibilização: dc.date.available2025-08-21T20:46:20Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbih.2021.100252-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240813-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240813-
Descrição: dc.descriptionEncephalopathy is one of the most frequent neurological complications of severe Coronavirus Disease 2019 (COVID-19) patients. Cytokine storm and sepsis, hypercatabolic states, the use of furosemide and dialytic therapy represent risk factors for thiamine deficiency and are also found in patients with severe COVID-19. In this retrospective case series, we report clinical and neurological findings of fifteen patients with COVID-19-associated Wernicke Encephalopathy (WE) and their response to treatment with intravenous thiamine. All patients had encephalopathy, with 67% displaying at least one additional sign of classic WE triad (ophthalmoparesis and ataxia). Two patients (13%) had the classic triad. All COVID-19 patients had significant improvement of the neurological manifestations between two to five days after intravenous thiamine administration. Eleven patients (73%) had good neurological outcome at hospital discharge and only two patients (13%) died. This case series suggests that thiamine deficiency may be an etiology of encephalopathy in severe COVID-19 patients and its treatment may represent a safety and low-cost response to reduce the neurological burden.-
Descrição: dc.descriptionUnimed Hospital of Araçatuba-
Descrição: dc.descriptionUniversity of the Region of Joinville (UNIVILLE)-
Descrição: dc.descriptionLaboratory of Psychoneuroimmunology Psychosomatic Research Center Oral Oncology Center Araçatuba Dental School São Paulo State University – UNESP-
Descrição: dc.descriptionLaboratory of Psychoneuroimmunology Psychosomatic Research Center Oral Oncology Center Araçatuba Dental School São Paulo State University – UNESP-
Idioma: dc.languageen-
Relação: dc.relationBrain, Behavior, and Immunity - Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute respiratory distress syndrome (ARDS)-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectDelirium-
Palavras-chave: dc.subjectEncephalopathy-
Palavras-chave: dc.subjectThiamine-
Palavras-chave: dc.subjectWernicke encephalopathy-
Título: dc.titleEncephalopathy responsive to thiamine in severe COVID-19 patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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