The growing field of immunometabolism and exercise: Key findings in the last 5 years

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Giessen-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Coimbra-
Autor(es): dc.creatorPadilha, Camila S.-
Autor(es): dc.creatorMorano, Ana E. Von Ah-
Autor(es): dc.creatorKrüger, Karsten-
Autor(es): dc.creatorRosa-Neto, José C.-
Autor(es): dc.creatorLira, Fabio S.-
Data de aceite: dc.date.accessioned2025-08-21T21:30:19Z-
Data de disponibilização: dc.date.available2025-08-21T21:30:19Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jcp.30866-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240757-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240757-
Descrição: dc.descriptionThis perspective review highlights the impact of physical exercise on immunometabolic responses in the past 5 years. Understanding immunometabolism as a part of immunological research is essential. Furthermore, the roles of both acute and chronic effects of physical exercise on health, aging, and chronic diseases in immunometabolic changes should be elaborated. In immune cells, β2 adrenergic signaling stimulates the preferential mobilization of inflammatory phenotypes, such as CD16+ monocytes and CD8+ T cells, into the bloodstream after a physical exercise session. The mobilization of immune cells is closely related to the availability of energetic substrates for the cell and mechanisms associated with the uptake and oxidation of fatty acids and glucose. These cells, especially senescent T cells, are mobilized to the peripheral tissues and undergo apoptotic signaling, stimulating the creation of a “vacant space” where new cells will be matured and replaced in the circulation. This results in the upregulation of the expression and secretion of anti-inflammatory cytokines (IL-10 and IL-1ra), leading to increased regulatory immune cells that provide immunoregulatory properties. Thus, we suggest that a significant nutrient available to the cell will favor oxidative metabolism, augment ATP production, and consequently maintain the immune cells in their quiescent state, as well as promote rapid activation function. Therefore, based on the studies discussed in this perspective review, we highlight the importance of performing moderate-intensity continuous and high-intensity intermittent aerobic exercises, due to a higher magnitude of energetic demand and release of anti-inflammatory cytokines (IL-6 and IL-10).-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education, Post-Graduate Program in Movement Sciences Laboratory of InVestigation in Exercise Scientific Research Group Related to Physical Activity Sao Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Exercise Physiology and Sports Therapy Institute of Sports Science University of Giessen-
Descrição: dc.descriptionImmunometabolism Research Group E LIM-26 University of São Paulo, SP-
Descrição: dc.descriptionFaculty of Sports Science and Physical Education Research Center for Sports and Physical Activity University of Coimbra-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education, Post-Graduate Program in Movement Sciences Laboratory of InVestigation in Exercise Scientific Research Group Related to Physical Activity Sao Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cellular Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectexercise-
Palavras-chave: dc.subjectimmune system-
Palavras-chave: dc.subjectimmunometabolic response-
Palavras-chave: dc.subjectmetabolic pathway-
Título: dc.titleThe growing field of immunometabolism and exercise: Key findings in the last 5 years-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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